CAY10792 |
| Catalog No.GC52245 |
An anticancer agent
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2361009-68-7
Sample solution is provided at 25 µL, 10mM.
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CAY10792 is an anticancer agent.1 It binds to heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37) in cell-free assays. CAY10792 inhibits the growth of A549, HCT116, U2OS, and MDA-MB-231 cancer cells (IC50s = 0.54, 0.59, 0.57, and 0.57 µM, respectively) but not A549 cells overexpressing Hsp90, Cdc37, or Hsp90 and Cdc37 (IC50s = >100 µM for all). It induces cell cycle arrest at the G0/G1 phase and apoptosis in A549 lung cancer cells when used at a concentration of 0.8 µM. In vivo, CAY10792 (0.5 and 1 mg/kg) reduces tumor weight in an A549 mouse xenograft model.
1.Li, N., Xu, M., Zhang, L., et al.Discovery of novel celastrol-imidazole derivatives with anticancer activity in vitro and in vivoJ. Med. Chem.65(6)4578-4589(2022)
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