CJC-1295 (Synonyms: Modified GRF (1-29), CJC-1295-no DAC, GHRH (1-29)-NH2)

Name: CJC-1295
Brand: GlpBio
SKU: GC47097
Availability: InStock
Rating: 5 (2 reviews)

Catalog No.GC47097

A synthetic peptide derivative of GHRH

Products are for research use only. Not for human use. We do not sell to patients.

CJC-1295 Chemical Structure

Cas No.: 446036-97-1

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5 mg	$43.00	In stock
25 mg	$161.00	In stock
50 mg	$301.00	In stock
100 mg	$556.00	In stock

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Sample solution is provided at 25 µL, 10mM.

GlpBio Products Cited In Reputable Papers

Nature
610.7931 (2022): 366-372

Nature
618, 1017–1023 (2023)

Cell
183.7 (2020): 1867-1883

Cell Research
31, 1291–1307 (2021)

Cell Research
33, 273–287 (2023)

Cell Research
33, 546–561 (2023)

Molecular Cancer
21.1 (2022): 1-17

Molecular Cancer
21.1 (2022): 1-18

Cancer Cell
39 (2021): 1-16

Cell Host Microbe
30.8 (2022): 1124-1138

Cell Host Microbe
31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

Description Chemical Properties Product Documents

Product Documents

Quality Control & SDS

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Purity: >95.00%

CJC-1295 is a synthetic peptide derivative of growth hormone-releasing hormone (GHRH).¹ Unlike CJC-1295-DAC, CJC-1295 does not contain a drug affinity complex (DAC) moiety and has a shorter half-life than the DAC-conjugated version in the blood.² CJC-1295 increases the secretion of growth hormone in primary rat anterior pituitary cells when used from picomolar to micromolar concentrations and into rat blood when administered subcutaneously at a dose of 1 µmol/kg.¹

1.Bridon, D.P., Boudjellab, N., Leger, R., et al.Long lasting growth hormone releasing factor derivatives(2002) 2.Teichman, S.L., Neale, A., Lawrence, B., et al.Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adultsJ. Clin. Endocrinol. Metab.91(3)799-805(2006)

Cas No.	446036-97-1	SDF
Synonyms	Modified GRF (1-29), CJC-1295-no DAC, GHRH (1-29)-NH2
Canonical SMILES	NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@]([H])([C@H](CC)C)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@H](C)NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC([C@H](C)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@]([H])(NC([C@H](CC1=CC=CC=C1)NC([C@]([H])([C@H](CC)C)NC([C@H](C)NC([C@@H](NC([C@@H](C)NC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)CC(O)=O)=O)=O)=O)=O)[C@@H](C)O)=O)CCC(N)=O)=O)CO)=O)CC3=CC=C(C=C3)O)=O)CCCNC(N)=N)=O)CCCCN)=O)C(C)C)=O)=O)=O)CCC(N)=O)=O)=O)CO)=O)=O)CCCNC(N)=N)=O)CCCCN)=O)=O)=O)CCC(N)=O)=O)CC(O)=O)=O)=O)=O)CO)=O)CCCNC(N)=N)=O
Formula	C152H252N44O42	M.Wt	3367.9
Solubility	DMF: slightly soluble,DMSO: 1mg/mL,Ethanol: slightly soluble	Storage	Store at -20°C
General tips	Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition	Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
		1 mg	5 mg	10 mg
	1 mM	0.2969 mL	1.4846 mL	2.9692 mL
	5 mM	0.0594 mL	0.2969 mL	0.5938 mL
	10 mM	0.0297 mL	0.1485 mL	0.2969 mL

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 2 reference(s) in Google Scholar.)

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CJC-1295 (Synonyms: Modified GRF (1-29), CJC-1295-no DAC, GHRH (1-29)-NH2)

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