Clofibric Acid-d4 (Synonyms: Chlorofibrinic acid-d4) |
Catalog No.GC49087
One-Click Copy Product Info
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An internal standard for the quantification of clofibric acid
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1184991-14-7
Sample solution is provided at 25 µL, 10mM.
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Clofibric acid-d4 is intended for use as an internal standard for the quantification of clofibric acid by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 µM in a transactivation assay) and the active metabolite of clofibrate .1 It is formed from clofibrate by tissue and serum esterases.2 Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats.3 It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (C. carpio) when administered in tank water at a concentration of 10 µg/L.4 Clofibric acid has been found in wastewater effluent.5
1.Giampietro, L., Laghezza, A., Cerchia, C., et al.Novel phenyldiazenyl fibrate analogues as PPAR α/γ/δ pan-agonists for the amelioration of metabolic syndromeACS Med. Chem. Lett.10(4)545-551(2019) 2.Cayen, M.N.Metabolic disposition of clofibrateDrug Metabol. Drug Interact.3(1 & 2)77-103(1980) 3.Cayen, M.N., Ferdinandi, E.S., Greselin, E., et al.Clofibrate and clofibric acid: Comparison of the metabolic disposition in rats and dogsJ. Pharmacol. Exp. Ther.200(1)33-43(1977) 4.Saravanan, M., Karthika, S., Malarvizhi, A., et al.Ecotoxicological impacts of clofibric acid and diclofenac in common carp (Cyprinus carpio) fingerlings: Hematological, biochemical, ionoregulatory and enzymological responsesJ. Hazard. Mater.195188-194(2011) 5.Tixier, C., Singer, H.P., Oellers, S., et al.Occurrence and fate of carbamazepine, clofibric acid, diclofenac, ibuprofen, ketoprofen, and naproxen in surface watersEnviron. Sci. Technol.37(6)1061-1068(2003)
| Cas No. | 1184991-14-7 | SDF | |
| Synonyms | Chlorofibrinic acid-d4 | ||
| Canonical SMILES | OC(C(C)(C)OC1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)=O | ||
| Formula | C10H7ClD4O3 | M.Wt | 218.7 |
| Solubility | Acetonitrile: soluble,DMSO: soluble,Methanol: soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.5725 mL | 22.8624 mL | 45.7247 mL |
| 5 mM | 914.5 μL | 4.5725 mL | 9.1449 mL |
| 10 mM | 457.2 μL | 2.2862 mL | 4.5725 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)