D-threo-PPMP (hydrochloride) (Synonyms: D-threo-1-phenyl-2-Palmitoylamino-3-morpholino-1-propanol) |
| Catalog No.GC47276 |
A GlyCer synthetase inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 139889-65-9
Sample solution is provided at 25 µL, 10mM.
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D-threo-PPMP is a glucosylceramide (GlyCer) synthetase inhibitor.1,2 It is the active enanantiomer and enzymatic inhibitory component of the racemic DL-threo-PPMP . In MDCK kidney epithelial cells, D-threo-PPMP induces a 70% reduction in cell growth in vitro at 20 µM and significantly inhibits DNA synthesis at 3 µM.3 [Matreya, LLC. Catalog No. 1865]
1.Shen, W., Henry, A.G., Paumier, K.L., et al.Inhibition of glucosylceramide synthase stimulates autophagy flux in neuronsJ. Neurochem.129(5)884-894(2014) 2.Lee, L., Abe, A., and Shayman, J.A.Improved inhibitors of glucosylceramide synthaseJ. Biol. Chem.274(21)14662-14669(1999) 3.Abe, A., Inokuchi, J.-i., Jimbo, M., et al.Improved inhibitors of glucosylceramide synthaseJ. Biochem.111(2)191-196(1992)
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