DiD perchlorate (Synonyms: D 307, DiIC18(5), NK 3175) |
| Catalog No.GC30543 |
DiD perchlorate is a lipophilic fluorescent dye that can rapidly and stably integrate into phospholipid cell membranes and is widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 127274-91-3
Sample solution is provided at 25 µL, 10mM.
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DiD perchlorate is a lipophilic fluorescent dye that can rapidly and stably integrate into phospholipid cell membranes and is widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins[1]. DiD exhibits distinct red fluorescence, which facilitates multicolor imaging and flow cytometry analysis of live cells[2]. DiD perchlorate has been used to label plasma membranes and endocytic organelles in bovine aortic endothelial cells and rat hippocampal slices[3]. DiD has also been used to assess proliferation in prostate cancer cell lines by flow cytometry, where cell populations with high DiD expression were associated with lower proliferation[3]. DiD is non-cytotoxic and detectable after three weeks in subcutaneously implanted PC3 cells in vivo[4]. DiD can be excited by 633nm helium-neon (He-Ne) laser, has a longer excitation and emission wavelength than Dil, and is especially suitable for labeling cells and tissues with background fluorescence.
References:
[1]. Yumoto, K., Berry, J.E., Taichman, R.S., et al.A novel method for monitoring tumor proliferation in vivo using fluorescent dye DiDCytometry A.85(6)548-555(2014).
[2]. Dailey, M.E., and Waite, M.Confocal imaging of microglial cell dynamics in hippocampal slice culturesMethods18(2)222-230(1999).
[3]. Lin, C.P., Lynch, M.C., and Kochevar, I.E.Reactive oxidizing species produced near the plasma membrane induce apoptosis in bovine aorta endothelial cellsExp. Cell Res.259(2)351-359(2000).
[4]. Ribeiro, T., Raja, S., Rodrigues, A.S., et al.NIR and visible perylenediimide-silica nanoparticles for laser scanning bioimagingDyes Pigments110227-234(2014)
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