Doxefazepam |
Catalog No.GC63590
One-Click Copy Product Info
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Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 40762-15-0
Sample solution is provided at 25 µL, 10mM.
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Doxefazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.
Groups of 50 male and 50 female Sprague-Dawley rats are given food containing sufficient Doxefazepam, a benzodiazepine derivative, to ensure intakes of 0, 3, 10, or 30 mg/kg/day. Rats are treated for 104 weeks and then euthanized. An extensive autopsy is performed on those animals that died intercurrently and on euthanized animals. The chronic administration of Doxefazepam does not influence the survival of the rats. A significant linear trend in the incidence of hepatocellular neoplasms, primarily benign, is observed in the female treated groups. This higher incidence is not associated to a higher occurrence of focal hyperplasia or other preneoplastic lesions in treated rats. The brain, a target organ for the pharmacological activity of Doxefazepam, is carefully examined to search for microscopic foci of proliferative cells. A total of 12 and 6 malignant gliomas are observed in male and female rats, respectively; only two are noticed at autopsy. These tumors are mainly of the oligodendroglioma type commonly found in aged rats[1]. Doxefazepam is investigated in a series of toxicological studies. Oral LD50 values are greater than 2000 mg/kg in mice, rats and dogs, while endoperitoneal LD50 values are 746 and 544 mg/kg in the mice and rats, respectively, and greater than 1000 mg/kg in the dogs[2].
[1]. Borelli G, et al. Carcinogenicity study of doxefazepam administered in the diet to Sprague-Dawley rats. Fundam Appl Toxicol. 1990 Jul;15(1):82-92.
[2]. Bertoli D, et al. Toxicological evaluations of the benzodiazepine doxefazepam. Arzneimittelforschung. 1989 Apr;39(4):480-4.
| Cas No. | 40762-15-0 | SDF | |
| Formula | C17H14ClFN2O3 | M.Wt | 348.76 |
| Solubility | Storage | Store at -20°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.8673 mL | 14.3365 mL | 28.673 mL |
| 5 mM | 573.5 μL | 2.8673 mL | 5.7346 mL |
| 10 mM | 286.7 μL | 1.4337 mL | 2.8673 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)