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Home >> Signaling Pathways >> Neuroscience >> GABA Receptor

GABA Receptor

GABA receptors are a class of receptors that respond to the GABA (neurotransmitter gamma-aminobutyric acid), the chief inhibitory neurotransmitter in the vertebrate central nervous system.

Products for  GABA Receptor

  1. Cat.No. Product Name Information
  2. GC74347 α-Casozepine α-Casozepine is a bioactive peptide derived from the α protein S1 casein in milk and has an affinity for γ-aminobutyric acid (GABA) receptors in the brain. α-Casozepine Chemical Structure
  3. GC63615 α-Thujone α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone Chemical Structure
  4. GC70650 γ-Acetylenic GABA hydrochloride γ-Acetylenic GABA (GAG) hydrochloride is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA hydrochloride Chemical Structure
  5. GC64508 γ-Aminobutyric acid-d6

    γ-Aminobutyric acid-d6 (4-Aminobutyric acid-d6) is the deuterium labeled γ-Aminobutyric acid.

     γ-Aminobutyric acid-d6 Chemical Structure
  6. GC11449 β-CCB

    benzodiazepine receptor ligand

     β-CCB Chemical Structure
  7. GC14834 (±)-Nipecotic acid

    (±)-Nipecotic Acid, (R,S)-Nipecotic Acid, 3-Piperidine Carboxylic Acid, DL-Piperidine 3-Carboxylic Acid

     GABA uptake inhibitor (±)-Nipecotic acid Chemical Structure
  8. GN10745 (+)-Bicuculline

    NSC 32192

     (+)-Bicucline ((+)-Bicucline )) is a competitive GABAA receptor antagonist with an IC50 of 2μM. (+)-Bicuculline Chemical Structure
  9. GC34954 (+)-Borneol

    D-Borneol, (1R)-(+)-Borneol, (+)-endo-Borneol

     (+)-Borneol Chemical Structure
  10. GC30933 (+)-Kavain

    Kawain, NSC 112162

    An Analytical Reference Standard

     (+)-Kavain Chemical Structure
  11. GC38677 (-)-α-Pinene

    NSC 7727

     (-)-α-Pinene is a monoterpene and shows sleep enhancing property through a direct binding to GABAA-benzodiazepine (BZD) receptors by acting as a partial modulator at the BZD binding site. (-)-α-Pinene Chemical Structure
  12. GC10065 (-)-Bicuculline methiodide GABAA receptor antagonist (-)-Bicuculline methiodide Chemical Structure
  13. GC16857 (-)-Bicuculline methobromide (-)-Bicuculline methobromide Chemical Structure
  14. GC15636 (-)-Bicuculline methochloride (-)-Bicuculline methochloride Chemical Structure
  15. GC30889 (-)-Securinine

    NSC 107413, L-Securinine

     An alkaloid (-)-Securinine Chemical Structure
  16. GC60000 (2S)-6-Prenylnaringenin

    (2S)-6-PN

     (2S)-6-Prenylnaringenin is the most efficient compound in forebrain. (2S)-6-Prenylnaringenin Chemical Structure
  17. GC66255 (E)-3,4,5-Trimethoxycinnamic acid

    TMCA

     (E)-3,4,5-Trimethoxycinnamic acid (TMCA) is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy. (E)-3,4,5-Trimethoxycinnamic acid Chemical Structure
  18. GC14111 (R)-baclofen GABA receptor agonist (R)-baclofen Chemical Structure
  19. GC34986 (R)-Baclofen hydrochloride

    (R)-Baclofen

     (R)-Baclofen hydrochloride (Arbaclofen hydrochloride) is a selective GABAB receptor agonist. (R)-Baclofen hydrochloride Chemical Structure
  20. GC15464 (S)-SNAP 5114 GABA uptake inhibitor (S)-SNAP 5114 Chemical Structure
  21. GC12927 (±)-Baclofen (±)-Baclofen is a lipophilic derivative of γ-aminobutyric acid (GABA), and it is an orally effective and selective agonist of the metabotropic GABAB receptor with an IC50 of 200nM. (±)-Baclofen Chemical Structure
  22. GC17223 17-PA GABAA receptor antagonist 17-PA Chemical Structure
  23. GC70652 2'MeO6MF 2'MeO6MF is a brain-penetrant positive allosteric modulator at α2β1γ2L and all α1-containing GABAA receptors. 2'MeO6MF Chemical Structure
  24. GC60017 2'-O-Methylisoliquiritigenin 2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA and GABA pathways, but does not put a very significant effect on ne NE pathway. 2'-O-Methylisoliquiritigenin Chemical Structure
  25. GC11267 2-Hydroxysaclofen GABAB receptor antagonist 2-Hydroxysaclofen Chemical Structure
  26. GC33703 3,4,5-Trimethoxycinnamic acid 3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifoliaWILLD, with anti-stress effect, prolonging the sleeping time in animals. 3,4,5-Trimethoxycinnamic acid Chemical Structure
  27. GC12506 3-Methyl-GABA GABA aminotransferase activator 3-Methyl-GABA Chemical Structure
  28. GC33504 4-Acetamidobutanoic acid (N-acetyl GABA)

    4-Acetamidobutanoic Acid, N-acetyl-4-Aminobutanoic Acid, N-acetyl-γ-Aminobutyric Acid, NSC 27423

     4-Acetamidobutanoic acid (N-acetyl GABA) (N-acetyl GABA), the main metabolite of GABA, exhibits antioxidant and antibacterial activities. 4-Acetamidobutanoic acid (N-acetyl GABA) Chemical Structure
  29. GC63628 4-Hydroxymidazolam 4-Hydroxymidazolam Chemical Structure
  30. GC30943 6,2'-Dihydroxyflavone 6,2'-Dihydroxyflavone is a novel antagonist of GABAA receptor. 6,2'-Dihydroxyflavone Chemical Structure
  31. GC11284 6-(4-Methoxyphenyl)-3-pyridazinamine GABAA receptor antagonist 6-(4-Methoxyphenyl)-3-pyridazinamine Chemical Structure
  32. GC30898 6-Methylflavone 6-Methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. 6-Methylflavone Chemical Structure
  33. GC10641 AA 29504 GABAA receptor modulator AA 29504 Chemical Structure
  34. GC14916 Acamprosate calcium

    N-acetyl Homotaurinate, N-acetyl Homotaurine

     An NMDA modulator Acamprosate calcium Chemical Structure
  35. GC62829 Afizagabar

    S44819; Egis-13529

     Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar Chemical Structure
  36. GC30844 Afloqualone

    HQ-495

     An Analytical Reference Standard Afloqualone Chemical Structure
  37. GC14192 Allopregnanolone

    ALLO, 3α,5α-tetrahydro Progesterone, 3α,5α-THP; brexanolone

     Allopregnanolone, a 3alpha, 5alpha progesterone metabolite, acts as a potent allosteric modulator of the γ-aminobutyric acid type A (GABAA) receptor, exerts antidepressant and neuroprotective action. Allopregnanolone Chemical Structure
  38. GC63495 Alogabat Alogabat (example 8) is a GABAA α5 receptor positive allosteric modulators (PAMs) (extracted from patent WO2018104419A1). Alogabat Chemical Structure
  39. GC30983 alpha-Asarone (α-Asarone)

    transAsarone

     alpha-Asarone (α-Asarone) (α-Asarone) is one of the main psychoactive compounds, and possesses an antidepressant-like activity in mice. alpha-Asarone (α-Asarone) Chemical Structure
  40. GC13515 Alphaxalone activates and potentiates GABAA receptor-activated membrane current (IGABA) Alphaxalone Chemical Structure
  41. GC45380 Aminooxyacetic Acid

    Aminooxyacetate

     Aminooxyacetic acid is a gamma-aminobutyric acid transaminase (GABA-T) inhibitor. Aminooxyacetic Acid Chemical Structure
  42. GC34064 Aminooxyacetic acid hemihydrochloride (Carboxymethoxylamine Hemihydrochloride)

    Aminooxyacetate

     Aminooxyacetic acid hemihydrochloride (Carboxymethoxylamine Hemihydrochloride) is an inhibitor of the malate-aspartate shuttle (MAS) and γ-aminobutyric acid transaminase (GABA-T). Aminooxyacetic acid hemihydrochloride (Carboxymethoxylamine Hemihydrochloride) Chemical Structure
  43. GC68659 Anisatin

    Anisatin is a toxic substance isolated from the seeds of a Japanese plant (Illicium anisatum). It is a non-competitive b>GABA antagonist and belongs to the class of convulsant toxins. Anisatin inhibits GABA-induced currents in a concentration-dependent manner, with an EC50 of approximately 1.10 μM.

     Anisatin Chemical Structure
  44. GA20775 Anxiety Peptide Anxiety Peptide, also known as Octadecaneuropeptide (ODN), is produced by trypsin digestion of diazepam binding inhibitor (DBI). Anxiety Peptide Chemical Structure
  45. GC60596 Arecaidine Arecaidine, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine Chemical Structure
  46. GC63879 Arecaidine hydrochloride Arecaidine hydrochloride, a pyridine alkaloid, is a potent GABA uptake inhibitor. Arecaidine hydrochloride Chemical Structure
  47. GC10974 AWD 131-138

    ELB138, Imepitoin

     AWD 131-138 (AWD 131-138) is a new low-affinity partial benzodiazepine receptor agonist with potent anticonvulsant and anxiolytic properties in rodent models. AWD 131-138 Chemical Structure
  48. GC31010 AZD-6280 AZD-6280 is a selective GABAA(α2/3) receptor modulator, used for treatment of generalized anxiety disorder. AZD-6280 Chemical Structure
  49. GC31990 Bamaluzole Bamaluzole is a GABA receptor agonist extracted from patent WO 2012064642 A1. Bamaluzole Chemical Structure
  50. GC19057 Basmisanil

    RG-1662

     Basmisanil is a highly selective GABAAα5 negative allosteric modulator. Basmisanil Chemical Structure
  51. GC12414 Bemegride GABA receptor antagonist Bemegride Chemical Structure
  52. GC34494 Bifenazate An acaricide Bifenazate Chemical Structure
  53. GC68798 BPDBA

    BPDBA is a selective and non-competitive inhibitor of betaine/GABA transporter (BGT-1), with IC50 values of 20 μM for human BGT-1 and 35 μM for mouse GAT2.

     BPDBA Chemical Structure
  54. GC11565 Bretazenil

    Ro 16-6028

     GABAA benzodiazepine site partial agonist Bretazenil Chemical Structure
  55. GC30521 Broflanilide Broflanilide is a meta‑diamide broad‑spectrum insecticide and acts as a pro‑insecticide that is metabolically converted to its active form, des‑methyl broflanilide, a potent non‑competitive antagonist at the insect resistant‑to‑dieldrin (RDL) γ‑aminobutyric acid (GABA) receptor (IC₅₀=1.3nM against Spodoptera litura RDL GABAR). Broflanilide Chemical Structure
  56. GC31224 Carburazepam (RGH 3331) Carburazepam (RGH 3331) is a drug which derives from benzodiazepine. Carburazepam (RGH 3331) Chemical Structure
  57. GC13374 CGP 13501 Positive modulator of GABAB receptors,allosteric CGP 13501 Chemical Structure
  58. GC11153 CGP 35348 Selective GABAB antagonist, brain penetrant CGP 35348 Chemical Structure
  59. GC13676 CGP 36216 hydrochloride Selective GABAB antagonist CGP 36216 hydrochloride Chemical Structure
  60. GC35669 CGP 36742

    3-Aminopropyl-n-butylphosphinic Acid, SGS 742

     CGP 36742 is a selective GABAB receptor antagonist that can penetrate the blood–brain barrier after peripheral administration, with an IC50 of 32?μM. CGP 36742 Chemical Structure
  61. GC13131 CGP 46381 GABAB receptor antagonist CGP 46381 Chemical Structure
  62. GC16947 CGP 52432 CGP 52432 is a GABAB receptor antagonist with an IC₅₀ of 85nM, which is 35- and 100-fold lower than those at receptors regulating somatostatin and glutamate overflow, respectively. CGP 52432 Chemical Structure
  63. GC10489 CGP 54626 hydrochloride

    CGP 54626A

    GABAB receptor antagonist

     CGP 54626 hydrochloride Chemical Structure
  64. GC16600 CGP 55845 hydrochloride GABAB receptor antagonist CGP 55845 hydrochloride Chemical Structure
  65. GC15563 CGP 7930 Positive allosteric modulator of GABAB receptors CGP 7930 Chemical Structure
  66. GC33751 CGP11952 CGP11952 is a triazolyl-Benzaphenon resembling the benzodiazepines in its pharmacological action. CGP11952 Chemical Structure
  67. GC14274 CGS 20625 partial agonist for the benzodiazepine binding site of the GABAA receptor CGS 20625 Chemical Structure
  68. GC16311 Chlormethiazole hydrochloride

    Clomethiazole

     GABAA agonist Chlormethiazole hydrochloride Chemical Structure
  69. GC16691 Chlormezanone

    (±)-Chlormezanone, NSC 169108

     Anxiolytic and skeletal muscle relaxant Chlormezanone Chemical Structure
  70. GC43261 Cholesteryl Myristate

    Cholesterol Myristate, Cholesteryl Tetradecanoate, Myristic Acid cholesteryl ester, NSC 226867

     Cholesteryl Myristate is a natural steroid present in traditional Chinese medicine. Cholesteryl Myristate binds to several ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel. Cholesteryl Myristate Chemical Structure
  71. GC14477 CI 966 hydrochloride GABA transporter GAT-1 inhibitor CI 966 hydrochloride Chemical Structure
  72. GC31120 Cirsimaritin

    5,4'-Dihydroxy-6,7-dimethoxyflavone

     Cirsimaritin is a dimethoxy flavonoid found in plants, it has anticancer potential and shows potent antimicrobial, antioxidant, antispasmodic, activity, and also inhibits cyclooxygenase-1. Cirsimaritin Chemical Structure
  73. GC16188 CL 218872 Benzodiazepine agonist CL 218872 Chemical Structure
  74. GC38758 Clomethiazole Chlormethiazole is an potent and orally active GABAA?agonist. Clomethiazole Chemical Structure
  75. GC60723 COR659 COR659 is a potent and effective GABAB positive allosteric modulator (PAM). COR659 Chemical Structure
  76. GC31052 CP-409092 CP-409092 is a partial agonist of GABAA receptor, with anti-anxiety activity. CP-409092 Chemical Structure
  77. GC38387 CP-409092 hydrochloride CP-409092 hydrochloride is a partial agonist of GABAA receptor, with anti-anxiety activity. CP-409092 hydrochloride Chemical Structure
  78. GC30930 DAA-1106 A TSPO agonist DAA-1106 Chemical Structure
  79. GC10530 Dihydroergotoxine mesylate GABAA receptor modulator Dihydroergotoxine mesylate Chemical Structure
  80. GC13405 DMCM hydrochloride Benzodiazepine inverse agonist DMCM hydrochloride Chemical Structure
  81. GC63590 Doxefazepam Doxefazepam Chemical Structure
  82. GC14150 DPNI-caged-GABA

    activates GABAA receptor

     DPNI-caged-GABA Chemical Structure
  83. GC12008 DS2 DS2 is a novel and selective positive allosteric modulator of δ-subunit-containing GABAA receptors. DS2 Chemical Structure
  84. GC35975 Emamectin Benzoate Emamectin Benzoate (MK-244) is an orally active nervoussystem toxicant by binding g-aminobutyric (GABA) receptor in insects. Emamectin Benzoate Chemical Structure
  85. GC11054 Epiallopregnanolone

    5α-Pregnan-20-one,3β,21-dihydroxy-5α-Pregnan-20-one,3β,5α-Tetrahydrodeoxycorticosterone,3β,5α-Tetrahydroprogesterone

     inactive as a GABAA receptor modulator and used as a control substance to examine GABA neurotransmission. Epiallopregnanolone Chemical Structure
  86. GC64673 Etbicyphat

    Trimethylopropane phosphate

     Etbicyphat (Trimethylopropane phosphate) is a potent GABA(A) receptors competitive antagonist. Etbicyphat Chemical Structure
  87. GC31023 Ethyl dirazepate Ethyl dirazepate is a drug which is a benzodiazepine derivative. Ethyl dirazepate Chemical Structure
  88. GC36012 Etifoxine

    Etafenoxine, HOE 36801

     A positive allosteric modulator of GABAA receptors Etifoxine Chemical Structure
  89. GC15264 Etifoxine hydrochloride A positive allosteric modulator of GABAA receptors Etifoxine hydrochloride Chemical Structure
  90. GC61788 Etiocholanolone

    5β-Androsterone, 3α-Etiocholanolone, NSC 50908

     An androgenically inactive metabolite of testosterone and androstenedione Etiocholanolone Chemical Structure
  91. GC16134 Etomidate

    (+)-Etomidate, d-Etomidate, R 16659

    General anesthetic with GABA modulatory and GABA-mimetic actions

     Etomidate Chemical Structure
  92. GC70546 Fengabine Fengabine is a GABAergic antidepressant agent. Fengabine Chemical Structure
  93. GC12568 FG 7142

    ZK 39106

     benzodiazepine inverse agonist and anxiogenic agent FG 7142 Chemical Structure
  94. GC33754 FG8119 (NNC13-8119)

    NNC13-8119

     FG8119 (NNC13-8119) is a novel benzodiazepine agonist extracted from patent US 4745112 A. FG8119 (NNC13-8119) Chemical Structure
  95. GC14017 FGIN-1-27

    high affinity agonist of the translocator protein (TSPO,peripheral benzodiazepine receptor)

     FGIN-1-27 Chemical Structure
  96. GC16238 FGIN-1-43 ligand as probe for the mitochondial DBI receptor (peripheral benzodiazepine receptor) FGIN-1-43 Chemical Structure
  97. GC60167 Fipronil An insecticide Fipronil Chemical Structure
  98. GC70576 Fipronil sulfone Fipronil sulfone is the major metabolite of Fipronil. Fipronil sulfone Chemical Structure
  99. GC10772 Flumazenil

    Ro 1722, Ro 15-1788, Ro 41-8157

    Benzodiazepine antagonist

     Flumazenil Chemical Structure
  100. GC36058 Flumazenil acid Flumazenil acid is a metabolite of Flumazenil. Flumazenil acid Chemical Structure
  101. GC30088 Fluxametamide Fluxametamide is an antagonist of GABA- and Glu-gated chloride channels (GABACls and GluCls) with IC50 value of 1.95nM and 225nM, respectively. Fluxametamide Chemical Structure

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