DSPE-PEG(2000)-amine |
Catalog No.GC43578
One-Click Copy Product Info
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DSPE-PEG(2000)-amine is the amine derivative of phospholipid poly ethylene glycol with biocompatible and biodegradable properties.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 474922-26-4
Sample solution is provided at 25 µL, 10mM.
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DSPE-PEG(2000)-amine is the amine derivative of phospholipid poly ethylene glycol with biocompatible and biodegradable properties [1]. DSPE-PEG(2000)-amine can be used to encapsulate liposomes and facilitate the passage of liposomes through the blood-brain barrier[2]. DSPE-PEG(2000)-amine can self-assemble into micelles and are easily modified, which participates in lipid transfer to design targeted liposomes, thereby protecting the targeting ligands during circulation[3]. DSPE-PEG(2000)-amine has been widely used in the preparation of liposomes and polymer nanoparticles to reduce the in vivo clearance rate and plasma protein adsorption of cholesterol-free lipid formulations, prolong the in vivo circulation time, increase targeting ability and improve bioavailability[4].
References:
[1] Sun F, Jaspers T C C, van Hasselt P M, et al. A Mixed Micelle Formulation for Oral Delivery of Vitamin K: Sun et al[J]. Pharmaceutical research, 2016, 33(9): 2168-2179.
[2] Vijayakumar M R, Kosuru R, Vuddanda P R, et al. Trans resveratrol loaded DSPE PEG 2000 coated liposomes: an evidence for prolonged systemic circulation and passive brain targeting[J]. Journal of drug delivery science and technology, 2016, 33: 125-135.
[3] Li W M, Xue L, Mayer L D, et al. Intermembrane transfer of polyethylene glycol-modified phosphatidylethanolamine as a means to reveal surface-associated binding ligands on liposomes[J]. Biochimica et Biophysica Acta (BBA)-Biomembranes, 2001, 1513(2): 193-206.
[4] Wang R, Xiao R, Zeng Z, et al. Application of poly (ethylene glycol)–distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers and their derivatives as nanomaterials in drug delivery[J]. International journal of nanomedicine, 2012: 4185-4198.
| Cas No. | 474922-26-4 | SDF | |
| Canonical SMILES | O=[P](OCCNC(OCCOCCN)=O)(O)OCC(COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O.N | ||
| Formula | (C2H4O)n C44H87N2O10P•NH3 | M.Wt | 2000(Average) |
| Solubility | DMF: 11 mg/ml,Ethanol: 20 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 500 μL | 2.5 mL | 5 mL |
| 5 mM | 100 μL | 500 μL | 1 mL |
| 10 mM | 50 μL | 250 μL | 500 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 31 reference(s) in Google Scholar.)