Edelfosine (Synonyms: 2-O-methyl PAF C-18) |
| Catalog No.GC16687 |
Edelfosine ((R)-ET-18-OCH3) is a ether lipid analog with anti-HIV and antineoplastic activity.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 77286-66-9
Sample solution is provided at 25 µL, 10mM.
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2-O-methyl-PAF C-18 is a synthetic PAF analog which contains a methyl group, attached by an ether linkage, at the sn-2 position. It has been shown to mediate a number of biological responses including decreasing plasma membrane fluidity and inhibiting tumor cell invasiveness in embryonic chick heart.[1] In rat astrocytes, 2-O-methyl PAF C-18 causes the release of large quantities of nitric oxide by a pathway involving activation of nitric oxide synthase.[2]
Reference:
[1]. van Blitterswijk, W.J., Hilkmann, H., and Storme, G.A. Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion. Lipids 22, 820-823 (1987).
[2]. Cardile, V., Jiang, X., Renis, M., et al. Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero-3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes. Brain Research 715, 98-103 (1996).
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