GLPBio

Proteases

Proteases - Signaling Pathways | GlpBio

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Proteases is a general term for a class of enzymes that hydrolyze protein peptide chains. According to the way they degrade polypeptides, they are divided into two categories: endopeptidases and telopeptidases. The former can cut the large molecular weight polypeptide chain from the middle to form prions and peptones with smaller molecular weights; the latter can be divided into carboxypeptidase and aminopeptidase, which respectively remove the peptide from the free carboxyl terminus or free amino terminus of the polypeptide one by one. Chain hydrolysis produces amino acids.

A general term for a class of enzymes that hydrolyze peptide bonds in proteins. According to the way they hydrolyze polypeptides, they can be divided into endopeptidases and exopeptidases. Endopeptidase cleaves the interior of the protein molecule to form smaller molecular weight peptones and peptones. Exopeptidase hydrolyzes peptide bonds one by one from the end of the free amino group or carboxyl group of protein molecules, and frees amino acids, the former is aminopeptidase and the latter is carboxypeptidase. Proteases can be classified into serine proteases, sulfhydryl proteases, metalloproteases and aspartic proteases according to their active centers and optimum pH. According to the optimum pH value of its reaction, it is divided into acidic protease, neutral protease and alkaline protease. The proteases used in industrial production are mainly endopeptidases.

Proteases are widely found in animal offal, plant stems and leaves, fruits and microorganisms. Microbial proteases are mainly produced by molds and bacteria, followed by yeast and actinomycetes.

Enzymes that catalyze the hydrolysis of proteins. There are many kinds, the important ones are pepsin, trypsin, cathepsin, papain and subtilisin. Proteases have strict selectivity for the reaction substrates they act on. A protease can only act on certain peptide bonds in protein molecules, such as the peptide bonds formed by the hydrolysis of basic amino acids catalyzed by trypsin. Proteases are widely distributed, mainly in the digestive tract of humans and animals, and are abundant in plants and microorganisms. Due to limited animal and plant resources, the industrial production of protease preparations is mainly prepared by fermentation of microorganisms such as Bacillus subtilis and Aspergillus terrestris.

Research Areas

Products Related to Proteases(4533)

  • GC81555 structure
    GC81555GPLGVRGC
    CAS: 1257658-47-1
    Purity: >98.00%

    GPLGVRG C is a cysteine-tagged variant of GPLGVRG.

  • GC81559 structure
    GC81559Maxadilan TFA
    Purity: >96.00%

    Maxadilan TFA is a specific irreversible PAC1 receptor agonist and a potent vasodilator peptide present in the salivary glands of sand flies.

  • GC81568 structure
    GC81568M464
    Purity: >99.50%

    M464, a non-steroidal anti-inflammatory compound, is a potent and orally active NLRP3 inflammasome inhibitor.

  • GC81571 structure
    GC815713,4,6-Tri-O-galloyl-D-glucose
    CAS: 99523-99-6
    Purity: >98%

    3,4,6-Tri-O-galloyl-D-glucose (3,4,6-Trigalloylglucose) is an α-amylase ( porcine α-amylase IC 50 = 334.6 μM; K i = 307.5 μM) and α-glucosidase ( yeast α-glucosidase IC 50 = 46.5 μM; K i = 39.9 μM) mixed type inhibitor.

  • GC81572 structure
    GC81572Glutathione trisulfide TFA
    Purity: >99.00%

    Glutathione trisulfide TFA (GSSSG TFA) is an orally active, blood-brain barrier permeable neuroprotective agent.

  • GC81574 structure
    GC81574Hydroxyproline
    CAS: 6912-67-0
    Purity: >98.00%

    Hydroxyproline (DL-Hydroxyproline) is a non-essential amino acid and one of the main components of collagenous tissues.

  • GC81576 structure
    GC81576USF 2550A
    CAS: 5192-62-1
    Purity: >98%

    USF 2550A is a class of fungus-derived 2-pyran compound with DPPH free radical scavenging activity.

  • GC81584 structure
    GC815842-Amino-2-deoxy-D-glucopyranose
    CAS: 90-77-7
    Purity: >98.00%

    2-Amino-2-deoxy-D-glucopyranose is an isomeric form of Glucosamine.

  • GC81592 structure
    GC81592ToP-DNJ
    CAS: 1508303-85-2
    Purity: >98%

    ToP-DNJ is a selective endoplasmic reticulum α-glucosidase II ( GluII ) inhibitor with an IC 50 value of 9.0 μM.

  • GC81595 structure
    GC81595BCS12
    CAS: 329719-71-3
    Purity: >99.50%

    BCS12 is a CAIX inhibitor.

  • GC81597 structure
    GC81597Momilactone B
    CAS: 51415-08-8
    Purity: >99.00%

    Momilactone B is an inhibitor of α-amylase and α-glucosidase, with an IC 50 of 146.85 μg/mL against Aspergillus oryzae α-amylase and an IC 50 of 612.03 μg/mL against Saccharomyces cerevisiae α-glucosidase.

  • GC81600 structure
    GC81600S-D-Lactoylglutathione
    CAS: 41656-56-8
    Purity: >98.50%

    S-D-Lactoylglutathione (S-Lactylglutathione; (R)-S-Lactoylglutathione) is a multifunctional metabolic intermediate of the glyoxalase system.

  • GC81601 structure
    GC816012-Hydroxymelatonin
    CAS: 229018-17-1
    Purity: >98.00%

    2-Hydroxymelatonin is a major hydroxylated metabolite of Melatonin.

  • GC81602 structure
    GC81602Glucosamine sulfate potassium chloride
    CAS: 1296149-08-0
    Purity: >98.00%

    Glucosamine sulfate potassium chloride is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement.

  • GC81603 structure
    GC816034’-Phosphopantetheine
    CAS: 2226-71-3
    Purity: >97.50%

    4’-Phosphopantetheine is an orally active coenzyme A (CoA) precursor.

  • GC81606 structure
    GC81606DX-8951 Hydroxy-acid sodium
    Purity: >98.50%

    DX-8951 Hydroxy-acid sodium is a prodrug of phosphoramide.

  • GC81612 structure
    GC81612Y1693
    CAS: 2812381-74-9
    Purity: >99.50%

    Y1693 is an orally active RANKL inhibitor with a K d of 5.03 μM for hRANKL.

  • GC81618 structure
    GC81618Urolithin A- 13 C 6
    Purity: >99.50%

    Urolithin A - 13 C 6 is the 13 C-labeled Urolithin A.

  • GC81628 structure
    GC81628Nicotinamide- 13 C, 15 N
    Purity: >98.50%

    Nicotinamide - 13 C, 15 N (Niacinamide- 13 C, 15 N) is the 13 C- and 15 N-labeled Nicotinamide.

  • GC81633 structure
    GC81633Malonyl CoA- 13 C 3 lithium
    Purity: >99.50%

    Malonyl CoA- 13 C 3 (Malonyl coenzyme A- 13 C 3 ) lithium is the 13 C-labeled Malonyl CoA lithium.

  • GC81634 structure
    GC816342-Acetamidophenol-d 3
    CAS: 122258-87-1
    Purity: >99.00%

    2-Acetamidophenol -d 3 (Orthocetamol-d 3 ) is the deuterium labeled 2-Acetamidophenol.

  • GC81638 structure
    GC81638PROTAC GPX4 degrader-5
    CAS: 3119292-91-7
    Purity: >95.00%

    PROTAC GPX4 degrader-5 (compound N15) is an efficient and highly selective PROTAC GPX4 degrader ( DC 50 = 28 nM).

  • GC81669 structure
    GC81669ATP- 13 C 10 , 15 N 5 ,d 14 (dilithium)
    Purity: >98%

    ATP- 13 C 10, 15 N 5,d 14 ( Adenosine 5'-triphosphate- 13 C 10, 15 N 5,d 14 ) dilithium is the 13 C-, 15 N- and deuterium labeled ATP dilithium.

  • GC81673 structure
    GC81673UE01
    CAS: 486440-74-8
    Purity: >98%

    UE01 is an orally active, selective small-molecule modulator targeting both ULK1/ERK1/2.