Rigin |
Catalog No.GA23485
One-Click Copy Product Info
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Rigin is an N-terminally palmitoylated tetrapeptide skincare active ingredient.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 77727-17-4
Sample solution is provided at 25 µL, 10mM.
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Rigin is an N-terminally palmitoylated tetrapeptide skincare active ingredient. Rigin can be used for research related to skin inflammaging, photoaging, and anti-wrinkle cosmetic ingredients[1-4].
In vitro, Rigin (2.2μM) was co-administered with palmitoyl oligopeptide (4.7μM) to human dermal fibroblasts for 3 days. Rigin promoted the synthesis of collagen I, fibronectin, and hyaluronan, and upregulated the expression of procollagen, lysyl oxidase, fibronectin, laminin, and other related genes[5].
In vivo, Rigin (3% or 5% gel; 100μL per application) was topically applied to PM10-treated SKH-1 hairless mice (the dorsal skin of 1cm² was first treated with 10μL of PM10 suspension; the peptide gel was applied daily) for 4 consecutive weeks. Rigin reduced PM10-induced expression of IL-1β and IL-6 in the skin[6].
References:
[1] Zhao C, Li D, Li J, et al. Molecular tandem repeat strategy for production ofultrashort peptides, et al. Sheng Wu Gong Cheng Xue Bao. 2022 Dec 25;38(12):4587-4600.
[2] Veretennikova NI, Chipens GI, Nikiforovich GV, et al. Rigin, another phagocytosis-stimulating tetrapeptide isolated from human IgG. Confirmations of a hypothesis. Int J Pept Protein Res. 1981 Apr;17(4):430-5.
[3] Rocchi R, Biondi L, Cavaggion F, et al. Synthesis and biological activity of tuftsin and rigin derivatives containing monosaccharides or monosaccharide derivatives. Int J Pept Protein Res. 1987 Feb;29(2):262-75.
[4] Porras M, Hernández D, Boto A. Antifungal Peptides with Unexpected Structure from a Library of Synthetic Analogs of Host-Defense Peptide Rigin. Int J Mol Sci. 2025 Feb 22;26(5):1900.
[5] Mondon P, Hillion M, Peschard O, et al. Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications. J Cosmet Dermatol. 2015 Jun;14(2):152-60.
[6] Min-Kyeong Kim, Min-Jung Kim, Ju-Weon Kim, et al. Control Effect of Palmitoyl Teterapeptide-7 Gel to Inflammatory Responses Elicited by PM10. Asian Journal of Beauty and Cosmetology. 2021 Jun; 19(2):165-174.
| Cell experiment [1]: | |
Cell lines | Human dermal fibroblasts (HDF) |
Preparation Method | Human dermal fibroblasts were treated with a blend of palmitoyl oligopeptide (4.7μM) and Rigin (2.2μM). After treatment, culture medium was collected for ELISA-based quantification of extracellular matrix components. |
Reaction Conditions | 2.2μM; 3 days |
Applications | Rigin significantly increased the synthesis of collagen I, fibronectin, and hyaluronan. Rigin upregulated expression of pro-collagen, lysyl oxidase, fibronectin, and laminin genes. |
| Animal experiment [2]: | |
Animal models | 6-week-old male SKH-1 hairless mice |
Preparation Method | The dorsal skin (1cm²) of hairless mice was topically applied with PM10 suspension (10μL) to induce cutaneous inflammatory response. Subsequently, 3% or 5% Rigin (100μL per application) was topically applied to the same site. After treatment, skin tissues were collected for immunohistochemistry and Western blot analysis to evaluate IL-1β and IL-6 expression levels. |
Dosage form | 3% or 5% in 100μL; topical application; 4 weeks |
Applications | Rigin reduced PM10-induced IL-1β and IL-6 expression in hairless mouse skin. In particular, the 5% Rigin group showed statistically significant decreases in both IL-1β and IL-6 expression compared with the PM10-only group. |
References: | |
| Cas No. | 77727-17-4 | SDF | |
| Formula | C18H32N8O6 | M.Wt | 456.5 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.1906 mL | 10.9529 mL | 21.9058 mL |
| 5 mM | 438.1 μL | 2.1906 mL | 4.3812 mL |
| 10 mM | 219.1 μL | 1.0953 mL | 2.1906 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)