ESI-05 (Synonyms: NSC 116966) |
| Catalog No.GC36007 |
An Epac2 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 5184-64-5
Sample solution is provided at 25 µL, 10mM.
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ESI-05 (NSC 116966) is a specific antagonist of EPAC2 (exchange protein directly activated by cAMP 2), with an IC50 of 0.4 µM. ESI-05 (NSC 116966) inhibits cAMP-mediated activation of EPAC2 as well as EAPC2 mediated Rap1 activation[1]. IC50: 0.4 µM (EPAC2)[1]
[1]. Tsalkova T, et al. Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8.
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