PF-03654746 Tosylate |
| Catalog No.GC38558 |
PF-03654746 Tosylate is a potent and selective histamine H3 receptor antagonist with high brain penetration.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1039399-17-1
Sample solution is provided at 25 µL, 10mM.
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PF-03654746 Tosylate is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 Tosylate reduces allergen-induced nasal symptoms[1]. PF-03654746 Tosylate has potential for treatment of human cognitive disorders, improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD)[2].
[1]. Stokes JR, et al. The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2. [2]. Brioni JD, et al. Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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