Home>>Analytical Standards>>Estrone-d2

Estrone-d2 (Synonyms: E1-d2)

Catalog No.GC45452

 

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Estrone-d2 Chemical Structure

Cas No.: 350820-16-5

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500μg
$49.00
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1mg
$94.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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Background

Estrone-d2 is intended for use as an internal standard for the quantification of estrone by GC- or LC-MS. Estrone is one of the three naturally occurring estrogens, the others being estradiol and estriol .1 Estrone is synthesized from androstenedione by the aromatase enzyme system in the ovaries and placenta, and is also synthesized from estradiol by 17-hydroxy steroid dehydrogenase in the liver.1,2 Serum concentrations of estrone in premenopausal women fluctuate according to the menstrual cycle and becomes the most predominant estrogen in postmenopausal women.1 The binding affinities of estrone to the estrogen receptors α and β are approximately 60% and 37% relative to estradiol.1

References
1. Gruber, C.J., Tschugguel, W., Schneeberger, C., et al. Production and actions of estrogens. New England Journal of Medicine 346(5), 340-352 (2002).

Chemical Properties

Cas No. 350820-16-5 SDF
Synonyms E1-d2
Canonical SMILES O=C1CC[C@@]2([H])[C@]3([H])CCC4=C([2H])C(O)=C([2H])C=C4[C@@]3([H])CC[C@@]21C
Formula C18H20D2O2 M.Wt 272.4
Solubility DMF: 30 mg/mL,DMF:PBS (pH 7.2) (1:5): 0.15 mg/mL,DMSO: 20 mg/mL Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.6711 mL 18.3554 mL 36.7107 mL
5 mM 0.7342 mL 3.6711 mL 7.3421 mL
10 mM 0.3671 mL 1.8355 mL 3.6711 mL
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