H-Gly-Arg-pNA (hydrochloride) (Synonyms: Gly-Arg-4-NA, GR-pNA, GR p-nitroanilide) |
| Catalog No.GC45471 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 125455-61-0
Sample solution is provided at 25 µL, 10mM.
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H-Gly-Arg-pNA is a colorimetric substrate for thrombin.1,2 Thrombin preferentially binds to and cleaves the Gly-Arg (GR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of thrombin activity.
References
1. Hortin, G.L., Warshawsky, I., and Laude-Sharp, M. Macromolecular chromogenic substrates for measuring proteinase activity. Clin. Chem. 47(2), 215-222 (2001).
2. Rijkers, D.T., Wielders, S.J., Tesser, G.I., et al. Design and synthesis of thrombin substrates with modified kinetic parameters. Thromb. Res. 79(5-6), 491-499 (1995).
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