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Linoleic Acid-d11

Catalog No.GC45499

Linoleic Acid-d11 Chemical Structure

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Sample solution is provided at 25 µL, 10mM.

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Linoleic acid-d11 contains 11 deuterium atoms at the 14, 14', 15, 15', 16, 16', 17, 17', 18, 18, and 18 positions. It is intended for use as an internal standard for the quantification of linoleic acid by GC- or LC-mass spectrometry. Linoleic acid is a PUFA found in plant tissues and most cooking oils. Deficiencies in the essential fatty acid linoleic acid are linked to coronary heart disease, growth retardation, and allergies.1,2 Linoleic acid can be metabolized by prostaglandin H synthases (PGHS) to form 9- and 13-HODE.3 The Km is 12 μM for human PGHS-1 and 27 μM for PGHS-2.3

1. Hashimoto, A., Katagiri, M., Torii, S., et al. Effect of the dietary α-linolenate/linoleate balance on leukotriene production and histamine release in rats. Prostaglandins 36, 3-15 (1988).
2. Laneuville, O., Breuer, D.K., Xu, N., et al. Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z,13E/Z,15Z)-octadecatrienoic acids from α-linolenic acid. The Journal of Biological Chemisty 270, 19330-19336 (1995).
3. Soyland, E., Fund, J., Rajka, G., et al. Effect of dietary supplementation with very-long-chain n-3 fatty acids in patients with psoriasis. N. Engl. J. Med. 328, 1812-1816 (1993).

Chemical Properties

Cas No. N/A SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES [2H]C(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])([2H])/C=C\C/C=C\CCCCCCCC(O)=O
Formula C18H21D11O2 M.Wt 291.5
Solubility 0.15 M Tris-HCl pH 8.5: 1 mg/ml,DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2): 100 µ g/ml Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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