Linoleic acid-d11 contains 11 deuterium atoms at the 14, 14', 15, 15', 16, 16', 17, 17', 18, 18, and 18 positions. It is intended for use as an internal standard for the quantification of linoleic acid by GC- or LC-mass spectrometry. Linoleic acid is a PUFA found in plant tissues and most cooking oils. Deficiencies in the essential fatty acid linoleic acid are linked to coronary heart disease, growth retardation, and allergies.1,2 Linoleic acid can be metabolized by prostaglandin H synthases (PGHS) to form 9- and 13-HODE.3 The Km is 12 μM for human PGHS-1 and 27 μM for PGHS-2.3
References
1. Hashimoto, A., Katagiri, M., Torii, S., et al. Effect of the dietary α-linolenate/linoleate balance on leukotriene production and histamine release in rats. Prostaglandins 36, 3-15 (1988).
2. Laneuville, O., Breuer, D.K., Xu, N., et al. Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z,13E/Z,15Z)-octadecatrienoic acids from α-linolenic acid. The Journal of Biological Chemisty 270, 19330-19336 (1995).
3. Soyland, E., Fund, J., Rajka, G., et al. Effect of dietary supplementation with very-long-chain n-3 fatty acids in patients with psoriasis. N. Engl. J. Med. 328, 1812-1816 (1993).