Gestodene-d6 (Synonyms: SHB 331-d6; WL 70-d6) |
Catalog No.GC48763
One-Click Copy Product Info
|
An internal standard for the quantification of gestodene
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1542211-40-4
Sample solution is provided at 25 µL, 10mM.
_1-3.$$$39978408@51.jpg');)
_1-9.$$$38538795@65.jpg');)
_1-9.$$$39112701@51.jpg');)
_1-7.$$$37316672@70.jpg');)
_366-372.$$$36198801@70.jpg');)
.$$$38565142@65.jpg');)
_1867-1883.$$$33248023@67.jpg');)
_eads6055.$$$39977546@45.jpg');)
_eadm9805.$$$40080571@45.jpg');)
_eadj3020.$$$39666821@45.jpg');)
_1-20.$$$39757301@28.jpg');)
_1-24.$$$38898113@28.jpg');)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
_1-19.$$$37460805@44.jpg');)
_1291-1307.$$$34518654@46.jpg');)
Gestodene-d6 is intended for use as an internal standard for the quantification of gestodene by GC- or LC-MS. Gestodene is a progestin.1 It selectively binds to the progesterone receptor over the estrogen receptor.2 Gestodene induces transcriptional activity mediated by the progesterone receptor, and, weakly, the androgen receptor in reporter assays.3 It increases the growth of MCF-7 cells when used at concentrations ranging from 0.1 to 1 µM.4 In contrast, gestodene (0.1 mg/kg) reduces tumor growth in an estrogen-dependent model of rat mammary tumors induced by DMBA . Formulations containing gestodene, in combination with ethynyl estradiol have been used as oral contraceptives.
1.Stanczyk, F.Z.All progestins are not created equalSteroids68(10-13)879-890(2003) 2.Pollow, K., Juchem, M., Grill, H.J., et al.Lack of binding of gestodene to estrogen receptor in human breast cancer tissueEur. J. Cancer26(5)608-610(1990) 3.Fuhrmann, U., Slater, E.P., and Fritzemeier, K.H.Characterization of the novel progestin gestodene by receptor binding studies and transactivation assaysContraception51(1)45-52(1995) 4.Kloosterboer, H.J., Schoonen, W.G., Deckers, G.H.J., et al.Effects of progestagens and Org OD14 in in vitro and in vivo tumor modelsJ. Steroid Biochem. Mol. Biol.49(4-6)311-318(1994)
| Cas No. | 1542211-40-4 | SDF | |
| Synonyms | SHB 331-d6; WL 70-d6 | ||
| Canonical SMILES | CC[C@@]12[C@](C=C[C@@]2(O)C#C)([H])[C@@]3([H])[C@]([C@]4([2H])C(C([2H])([2H])C3)=C([2H])C(C([2H])([2H])C4)=O)([H])CC1 | ||
| Formula | C21H20D6O2 | M.Wt | 316.5 |
| Solubility | Methanol: soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.1596 mL | 15.7978 mL | 31.5956 mL |
| 5 mM | 631.9 μL | 3.1596 mL | 6.3191 mL |
| 10 mM | 316 μL | 1.5798 mL | 3.1596 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)