Histone H3 (Citrullinated R26) (21-44)-GGK-biotin Peptide (trifluoroacetate salt) (Synonyms: ATKAA-Cit-KSAPATGGVKKPHRYRPG-GGK(Biotin), H3R26Cit, Histone H3 (21-44) (Arg26cit), Cit26-Histone H3 (21-44)-GGK(Biotin))

Name: Histone H3 (Citrullinated R26) (21-44)-GGK-biotin Peptide (trifluoroacetate salt)
Brand: GlpBio
SKU: GC52479
Availability: InStock
Rating: 5 (30 reviews)

Catalog No.GC52479

A biotinylated peptide fragment of histone H3

Products are for research use only. Not for human use. We do not sell to patients.

Histone H3 (Citrullinated R26) (21-44)-GGK-biotin Peptide (trifluoroacetate salt) Chemical Structure

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250 μg

$315.00

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Sample solution is provided at 25 µL, 10mM.

GlpBio Products Cited In Reputable Papers

Nature
610.7931 (2022): 366-372

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618, 1017–1023 (2023)

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183.7 (2020): 1867-1883

Cell Research
31, 1291–1307 (2021)

Cell Research
33, 273–287 (2023)

Cell Research
33, 546–561 (2023)

Molecular Cancer
21.1 (2022): 1-17

Molecular Cancer
21.1 (2022): 1-18

Cancer Cell
39 (2021): 1-16

Cell Host Microbe
30.8 (2022): 1124-1138

Cell Host Microbe
31.5 (2023): 766-780

Cell Host Microbe
31.3 (2023): 418-43

Cell Metabolism
34.2 (2022): 240-255

Ann Rheum Dis
82(4): 533-545 (2023)

Cell Mol Immunol
20, 264–276 (2023)

Adv Funct Mater
33.35 (2023): 2214998

Description Chemical Properties Product Documents

Product Documents

Quality Control & SDS

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Purity: >95.00%

Histone H3 (citrullinated R26) (21-44)-GGK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human H3.1 and H3.2 sequences. It is citrullinated at arginine 26 and biotinylated via a C-terminal GGK linker. Citrullination of histone H3 at arginine 26 occurs via deimination of the arginine residue by protein arginine deiminase 2 (PAD2) or PAD4 and is associated with transcriptional activation.^1,2,3 It inhibits methylation of H3K27 and is elevated in bone marrow mesenchymal stem cells (BMMSCs) derived from patients with monoclonal gammopathy of undetermined significance (MGUS) or multiple myeloma.^1,2

1.Clancy, K.W., Russell, A.-M., Subramanian, V., et al.Citrullination/methylation crosstalk on histone H3 regulates ER-target gene transcriptionACS Chem. Biol.12(6)1691-1702(2017) 2.McNee, G., Eales, K.L., Wei, W., et al.Citrullination of histone H3 drives IL-6 production by bone marrow mesenchymal stem cells in MGUS and multiple myelomaLeukemia31(2)373-381(2017) 3.Fuhrmann, J., and Thompson, P.R.Protein arginine methylation and citrullination in epigenetic regulationACS Chem. Biol.11(3)654-668(2016)

Cas No.		SDF	Download SDF
Synonyms	ATKAA-Cit-KSAPATGGVKKPHRYRPG-GGK(Biotin), H3R26Cit, Histone H3 (21-44) (Arg26cit), Cit26-Histone H3 (21-44)-GGK(Biotin)
Canonical SMILES	O=C(O)C(F)(F)F.O=C(CCCC[C@@H]1SC[C@@]([H])([C@@]1(N2)[H])NC2=O)NCCCC[C@H](NC(CNC(CNC(CNC([C@@H]3CCCN3C([C@@H](NC([C@H](CC4=CC=C(C=C4)O)NC([C@@H](NC([C@H](CC5=CN=CN5)NC([C@@H]6CCCN6C([C@@H](NC([C@@H](NC([C@@H](NC(CNC(CNC([C@@]([H])(NC([C@H](C)NC([C@@H]7CCCN7C([C@H](C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)NC([C@H](C)NC([C@@H](NC([C@@]([H])(NC([C@H](C)N)=O)[C@H](O)C)=O)CCCCN)=O)=O)=O)CCCNC(N)=O)=O)CCCCN)=O)CO)=O)=O)=O)=O)[C@H](O)C)=O)=O)=O)C(C)C)=O)CCCCN)=O)CCCCN)=O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)C(O)=O
Formula	C129H216N44O35S ? XCF3COOH	M.Wt	2975.5
Solubility	Water: 1 mg/ml	Storage	-20°C
General tips	Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition	Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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		1 mg	5 mg	10 mg
	1 mM	0.3361 mL	1.6804 mL	3.3608 mL
	5 mM	0.0672 mL	0.3361 mL	0.6722 mL
	10 mM	0.0336 mL	0.168 mL	0.3361 mL

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Reviews

Review for Histone H3 (Citrullinated R26) (21-44)-GGK-biotin Peptide (trifluoroacetate salt)

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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Histone H3 (Citrullinated R26) (21-44)-GGK-biotin Peptide (trifluoroacetate salt) (Synonyms: ATKAA-Cit-KSAPATGGVKKPHRYRPG-GGK(Biotin), H3R26Cit, Histone H3 (21-44) (Arg26cit), Cit26-Histone H3 (21-44)-GGK(Biotin))

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