Hygromycin A (Synonyms: (-)-Hygromycin A, Totomycin) |
Catalog No.GC49694 |
An antibiotic
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 6379-56-2
Sample solution is provided at 25 µL, 10mM.
Hygromycin A is an antibiotic originally isolated from S. hygroscopicus.1 It is active against numerous spirochete bacteria, including T. pallidum, L. biflexa, and four strains of B. burgdorferi (MICs = 0.03-4 µg/ml for all). Hygromycin A binds to the peptidyl transferase center (PTC) in the 70S ribosomal subunit to inhibit protein synthesis. It completely eliminates bacterial infection in skin biopsies from B. burgdorferi-infected mice in a model of acute Lyme disease when administered at doses ranging from 50 to 250 mg/kg twice per day.
1.Leimer, N., Wu, X., Imai, Y., et al.A selective antibiotic for Lyme diseaseCell184(21)5405-5418.e5416(2021)
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