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ICA 110381

Catalog No.GC10560

KV7.2/7.3 activator

Products are for research use only. Not for human use. We do not sell to patients.

ICA 110381 Chemical Structure

Cas No.: 325457-99-6

Size Price Stock Qty
10mg
$209.00
Ship Within 7 Days
50mg
$879.00
Ship Within 7 Days

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1].

References:
[1]. Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4.

Chemical Properties

Cas No. 325457-99-6 SDF
Chemical Name 4-chloro-N-(6-chloropyridin-3-yl)benzamide
Canonical SMILES ClC1=CC=C(C=C1)C(NC2=CC=C(N=C2)Cl)=O
Formula C12H8Cl2N2O M.Wt 267.11
Solubility <26.71mg/ml in DMSO; <5.34mg/ml in ethanol Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 38 reference(s) in Google Scholar.)

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