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ICA 110381

Catalog No.GC10560

KV7.2/7.3 activator

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ICA 110381 Chemical Structure

Cas No.: 325457-99-6

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1].

[1]. Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4.

Chemical Properties

Cas No. 325457-99-6 SDF
Chemical Name 4-chloro-N-(6-chloropyridin-3-yl)benzamide
Canonical SMILES ClC1=CC=C(C=C1)C(NC2=CC=C(N=C2)Cl)=O
Formula C12H8Cl2N2O M.Wt 267.11
Solubility <26.71mg/ml in DMSO; <5.34mg/ml in ethanol Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Review for ICA 110381

Average Rating: 5 ★★★★★ (Based on Reviews and 38 reference(s) in Google Scholar.)

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