JWH 412 |
Catalog No.GC18587
One-Click Copy Product Info
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JWH 412 is a positional isomer of AM2201 that was identified in the ‘herbal mixture'-XoXo.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1364933-59-4
Sample solution is provided at 25 µL, 10mM.
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JWH 412 is a positional isomer of AM2201 that was identified in the ‘herbal mixture’ XoXo.1 The substitution of hydrogen against fluorine in the 4-position of the naphthyl moiety enhances the binding affinity to the central cannabinoid (CB1) receptor compared to the unsubstituted JWH 018.[1] JWH 412 demonstrates Ki values of 7.2 and 3.2 nM at CB1 and peripheral CB2 receptors, respectively.[2] This product is intended for research and forensic purposes.
Reference:
[1]. Moosmann, B., Kneisel, S., Girreser, U., et al. Separation and structural characterization of the synthetic cannabinoids JWH-412 and 1-[(5-fluoropentyl)-1H-indol-3yl]-(4-methylnaphthalen-1-yl)methanone using GC-MS, NMR analysis and a flash chromatography system. Forensic Science International 220(1-3), e17-e22 (2012).
[2]. Smith, V.J. Synthesis and pharmacology of N-alkyl-3-(halonaphthoyl)indoles. Doctor of Philosophy Chemistry, 1-179-179 (2008).
| Cas No. | 1364933-59-4 | SDF | |
| Chemical Name | (4-fluoro-1-naphthalenyl)(1-pentyl-1H-indol-3-yl)-methanone | ||
| Canonical SMILES | O=C(C1=C2C=CC=CC2=C(F)C=C1)C3=CN(CCCCC)C4=C3C=CC=C4 | ||
| Formula | C24H22FNO | M.Wt | 359.4 |
| Solubility | 5mg/mL in ethanol, 20mg/mL in DMSO, or in DMF | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7824 mL | 13.9121 mL | 27.8242 mL |
| 5 mM | 556.5 μL | 2.7824 mL | 5.5648 mL |
| 10 mM | 278.2 μL | 1.3912 mL | 2.7824 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)