LSN2463359 |
| Catalog No.GC18309 |
LSN2463359 is a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5; EC50 = 24 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1401031-52-4
Sample solution is provided at 25 µL, 10mM.
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LSN2463359 is a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5; EC50 = 24 nM). It is without effect at other mGluRs. LSN2463359 is brain penetrant and reverses learning deficits in a rat model of schizophrenia. Through its effects on mGluR5, LSN2463359 attenuates deficits in performance in operant behavior induced by SDZ-220581, an NMDA receptor antagonist, in rats. It also promotes wakefulness in animals.
Review for LSN2463359
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
Review for LSN2463359
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