M40 (trifluoroacetate salt) (Synonyms: Galanin-(1-12)-Pro3-(Ala-Leu)2-Ala amide) |
Catalog No.GC91855
One-Click Copy Product Info
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M40 is a chimeric galanin-derived peptide and galanin-1 (GAL1) receptor antagonist and GAL2 receptor agonist (Kis = 2.4 and 4.07 nM, respectively).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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M40 is a chimeric galanin-derived peptide and galanin-1 (GAL1) receptor antagonist and GAL2 receptor agonist (Kis = 2.4 and 4.07 nM, respectively).[1],[2] It is selective for the GAL1 and GAL2 receptors over the GAL3 receptor (Ki = 288 nM).[1] M40 induces inositol phosphate accumulation in CHO cells expressing the human GAL2 receptor (EC50 = 16.2 nM) and inhibits forskolin-induced cAMP accumulation in RIN-m5F pancreatic β-cells when used at concentrations of 10 or 100 nM.[1],[2] In vivo, M40 (9.36 nmol/animal, i.c.v.) reverses galanin-induced inhibition of scopolamine-induced hippocampal acetylcholine (ACh) release in conscious rats.[2] M40 reduces galanin-induced increases in food intake in rats. It improves cardiac function and decreases cardiac fibrosis in a rat model of heart failure induced by sustained coronary artery ligation when administered at a dose of 30 nmol/kg.[3] M40 (20 µg/animal) increases the intromission frequency and ejaculation latency in sexually sluggish male mice.[4]
References:
[1].Borowsky, B., Walker, M.W., Huang, L.Y., et al.Cloning and characterization of the human galanin GALR2 receptorPeptides19(10)1771-1781(1998).
[2].Bartfai, T., Langel, Ü., Bedecs, K., et al.Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypesProc. Natl. Acad. Sci. USA90(23)11287-11291(1993).
[3].Chen, A., Li, M., Song, L., et al.Effects of the galanin receptor antagonist M40 on cardiac function and remodeling in rats with heart failureCardiovasc. Ther.33(5)288-293(2015).
[4].Benelli, A., Bertolini, A., Zoli, M., et al.Pharmacological manipulation of brain galaninergic system and sexual behavior in male micePsychopharmacology (Berl)160(3)325-330(2002).
| Cas No. | N/A | SDF | |
| Synonyms | Galanin-(1-12)-Pro3-(Ala-Leu)2-Ala amide | ||
| Formula | C94H145N23O24•XCF3COOH | M.Wt | 1981.3 |
| Solubility | Water: Soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 504.7 μL | 2.5236 mL | 5.0472 mL |
| 5 mM | 100.9 μL | 504.7 μL | 1.0094 mL |
| 10 mM | 50.5 μL | 252.4 μL | 504.7 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)