M62812 |
| Catalog No.GC50241 |
TLR-4 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 613263-00-6
Sample solution is provided at 25 µL, 10mM.
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TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic shock model.
Nakamura et al (2007) Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur.J.Pharmacol. 569 237 PMID:17588563
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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