| ATPγS tetralithium salt Catalog No.GC12574 |
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
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Purity >90.00%
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| Cas No. | 93839-89-5 | SDF | |
| Synonyms | N/A | ||
| Chemical Name | P'-anhydride with phosphorothioic acid adenosine 5'-(trihydrogen diphosphate), tetralithium salt | ||
| Canonical SMILES | S=P([O-])([O-])O[[email protected]](O[[email protected]](OC[[email protected]]1O[[email protected]@H]([[email protected]@H]([[email protected]@H]1O)O)N2C3=NC=NC(N)=C3N=C2)([O-])=O)([O-])=O.[Li+].[Li+].[Li+].[Li+] | ||
| Formula | C10H12Li4N5O12P3S | M.Wt | 546.98 |
| Solubility | 10mg/mL in PBS, pH 7.2 | Storage | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. | ||
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
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Adenosine 5'-(γ-thio)-triphosphate (lithium salt) is a stable analog of ATP that acts as a potent agonist of G protein-coupled P2Y2 and P2Y11 receptors (pEC50 = 5.52 for P2Y11).[1] It has been used to identify kinase substrates, has been implemented as a reagent in the synthesis of DNA N-acetylglucosamine analogs, and can serve as a substrate for the RNA-stimulated nucleotide hydrolysis and RNA unwinding activities of eukaryotic initiation factor-4A.[2],[3],[4]
Reference:
[1]. Jacobson, K.A., Ivanov, A.A., de Castro, S., et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 5(1), 75-89 (2009).
[2]. Knowles, J.R. Enzyme-catalyzed phosphoryl transfer reactions. Annual Reviews of Biochemistry 49, 877-919 (1980).
[3]. Chrysogelos, S., Register, J.C., III, and Griffith, J. The structure of recA protein-DNA filaments. 2 recA protein monomers unwind 17 base pairs of DNA by 11.5 degrees/base pair in the presence of adenosine 5'-O-(3-thiotriphosphate). The Journal of Biological Chemisty 258(20), 12624-12631 (1983).
[4]. Peck, M.L., and Herschlag, D. Adenosine 5'-O-(3-thio)triphosphate (ATPγS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor elF4A. RNA 9(10), 1180-1187 (2003).