ML 315 hydrochloride |
| Catalog No.GC50239 |
Inhibitor of Clk and DYRK kinases
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1440251-53-5
Sample solution is provided at 25 µL, 10mM.
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Inhibitor of cdc2-like kinases (Clk) and DYRK kinases (IC50 values are 68, 68 and 231 nM for Clk1, Clk4 and Clk2, respectively, and 282 and 1156 nM for Dyrk1A and Dyrk1B). Shows 20-fold selectivity for Clk4 over Dyrk1A. Stable in both mouse and human plasma. Moderately cell permeable.
Coombs et al (2013) Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg.Med.Chem.Lett. 23 3654 PMID:23642479
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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