N,N'-bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine |
| Catalog No.GC47720 |
A microbial metabolite with anticancer activity
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 30414-15-4
Sample solution is provided at 25 µL, 10mM.
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N,N'-bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine is a microbial metabolite and degradation product of the bacterial siderophore enterobactin that has been found in Streptomyces and has anticancer activity.1,2,3 It inhibits invasion of 26-L5 murine colon cancer cells in a Matrigel™ assay with an IC50 value of 2.7 µM.1
1.Igarashi, Y., Iida, T., Fukuda, T., et al.Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces spJ. Antibiot. (Tokyo)65(4)207-209(2012) 2.O'Brien, I.G., Cox, G.B., and Gibson, F.Enterochelin hydrolysis and iron metabolism in Escherichia coliBiochim. Biophys. Acta237(3)537-549(1971) 3.Raines, D.J., Moroz, O.V., Blagova, E.V., et al.Bacteria in an intense competition for iron: Key component of the Campylobacter jejuni iron uptake system scavenges enterobactin hydrolysis productProc. Nat. Acad. Sci. USA113(21)5850-5855(2016)
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