p-Cresol Glucuronide (Synonyms: 4-Cresol Glucuronide, p-Tolyl-β-D-glucuronide) |
| Catalog No.GC49414 |
A metabolite of p-cresol
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 17680-99-8
Sample solution is provided at 25 µL, 10mM.
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p-Cresol glucuronide is a metabolite of p-cresol, a uremic toxin formed by bacterial fermentation of proteins in the large intestine.1 It is formed from p-cresol primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A6, but also by UGT1A9, in human liver and kidney microsomes. p-Cresol glucuronide accumulates in feces, blood, and urine of patients with chronic kidney disease (CKD).2
1.Rong, Y., and Kiang, T.K.L.Characterizations of human UDP-glucuronosyltransferase enzymes in the conjugation of p-cresolToxicol. Sci.176(2)285-296(2020) 2.Gryp, T., De Paepe, K., Vanholder, R., et al.Gut microbiota generation of protein-bound uremic toxins and related metabolites is not altered at different stages of chronic kidney diseaseKidney Int.97(6)1230-1242(2020)
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