Home>>Analytical Standards>>PAF C-16-d4

PAF C-16-d4 (Synonyms: Plateletactivating Factor C16d4)

Catalog No.GC47855

An internal standard for the quantification of PAF C16

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PAF C-16-d4 Chemical Structure

Cas No.: 211106-54-6

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100 μg
$33.00
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500 μg
$147.00
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1 mg
$261.00
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Sample solution is provided at 25 µL, 10mM.

Description of PAF C-16-d4

PAF C-16-d4 contains four deuterium atoms at the 7, 7', 8, and 8' positions of the hexadecyl moiety. It is intended for use as an internal standard for the quantification of PAF C-16 by GC- or LC-mass spectrometry. PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the "remodeling" and 'de novo' pathways.1 It is a potent mediator of neutrophil migration,2 the production of reactive oxygen species,3 and IL-64 in human macrophages. It is a more potent mediator of platelet aggregation than PAF C-185. Pathological processes involving PAF include necrotizing enterocolitis,6 inflammation, asthma, and allergy.7

1.Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M.Platelet-activating factorThe Journal of Biological Chemisty26517381-17384(1990) 2.Carolan, E.J., and Casale, T.B.Degree of platelet activating factor-induced neutrophil migration is dependent upon the molecular speciesJournal of Immunology1452561-2565(1990) 3.Rouis, M., Nigon, F., and Chapman, M.J.Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophagesBiochemical and Biophysical Research Communications1561293-1301(1988) 4.Thivierge, M., and Rola-Pleszczynski, M.Platelet-activating factor enhances interleukin-6 production by alveolar macrophagesJournal of Allergy and Clinical Immunology90796-802(1992) 5.Stewart, A.G., and Grigoriadis, G.Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophagesJournal of Lipid Mediators4299-308(1991) 6.Wang, H., Tan, X.D., Qu, X.W., et al.Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: Effect of cycloheximidePediatric Research42597-603(1997) 7.Sturk, A., Wouter Ten Cate, J., Hosford, D., et al.The synthesis, catabolism, and pathophysiological role of platelet-activating factorAdvances in Lipid Research23219-276(1989)

Chemical Properties of PAF C-16-d4

Cas No. 211106-54-6 SDF
Synonyms Plateletactivating Factor C16d4
Canonical SMILES CCCCCCCCCCCCCCCCOC[C@H](COP(=O)(O)OCC[N](C)(C)C)OC(=O)C
Formula C26H50D4NO7P M.Wt 527.7
Solubility DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,PBS pH 7.2: 25 mg/ml,Water: 30 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of PAF C-16-d4

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1 mg 5 mg 10 mg
1 mM 1.895 mL 9.4751 mL 18.9502 mL
5 mM 0.379 mL 1.895 mL 3.79 mL
10 mM 0.1895 mL 0.9475 mL 1.895 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 12 reference(s) in Google Scholar.)

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