PAR3 (1-6) amide (mouse) (trifluoroacetate salt) (Synonyms: H-Ser-Phe-Asn-Gly-Gly-Pro-NH2, SFNGGP amide, SFNGGP-NH2, SFN-NH2) |
| Catalog No.GC44559 |
PAR3 (1-6) amide is a synthetic hexapeptide that corresponds to amino acid residues 1-6 of the amino terminal tethered ligand sequence of mouse proteinase-activated receptor 3 (PAR3) and residues 38-43 of the full-length sequence.
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Sample solution is provided at 25 µL, 10mM.
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PAR3 (1-6) amide is a synthetic hexapeptide that corresponds to amino acid residues 1-6 of the amino terminal tethered ligand sequence of mouse proteinase-activated receptor 3 (PAR3) and residues 38-43 of the full-length sequence. PAR3 (1-6) amide activates PAR1 and PAR2, but not PAR3 or PAR4. It does not induce thrombin signaling in COS-7 cells expressing PAR3, PAR4, or both receptors at concentrations less than or equal to 500 µM, however, it does activate PAR1 and PAR2 in a cross-desensitization assay in Jurkat T cells when used at concentrations of 500 and 1,000 µM. PAR3 (1-6) increases calcium levels in Kirsten virus-transformed rat kidney (KNRK) cells expressing rat or human PAR2, with a higher potency for rat PAR2.
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