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Pasireotide (aspartate)

Catalog No.GC44571

Pasireotide (aspartate) Chemical Structure

Size Price Stock
1mg
$150.00
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5mg
$674.00
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10mg
$1,198.00
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Sample solution is provided at 25 µL, 10mM.

Quality Control

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Background

Pasireotide is a somatostatin receptor (SSTR) agonist that binds selectively to SST1, SST2, SST3, and SST5 over SST4 (IC50s = 9.3, 1, 1.5, 0.16, and >100 nM, respectively, for human recombinant receptors). It dose-dependently inhibits growth hormone release stimulated by growth hormone-releasing hormone (GHRH) in primary rat anterior pituitary cells and inhibits adrenocorticotropic hormone (ACTH) secretion by some primary human corticotrope adenomas at a concentration of 10 nM. Pasireotide (10 nM) also inhibits ACTH release from and proliferation of mouse AtT20 pituitary corticotrope cells in vitro and inhibits tumor growth of subcutaneously implanted AtT20 cells in vivo in nude mice when administered at a dose of 1.5 μg per day. Pasireotide (0.03 mg/kg) decreases plasma ACTH concentrations and tumor size in dogs with ACTH-dependent Cushing's disease. Formulations containing pasireotide have been used in the treatment of acromegaly and Cushing's disease.

Chemical Properties

Cas No. 820232-50-6 SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C([C@H](CC1=CC=CC=C1)N2)N3[C@](C[C@@H](OC(NCCN)=O)C3)([H])C(N[C@H](C4=CC=CC=C4)C(N[C@H](CC5=CNC6=C5C=CC=C6)C(N[C@@H](CCCCN)C(N[C@@H](CC7=CC=C(OCC8=CC=CC=C8)C=C7)C2=O)=O)=O)=O)=O.OC(C[C@H](N)C(O)=O)=O.OC(C[C@H](N)C(O)=O)=O
Formula C58H66N10O9•2C4H7NO4 M.Wt 1313.4
Solubility Soluble in DMSO Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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