PF 06273340 |
| Catalog No.GC50346 |
Potent and selective pan-Trk inhibitor; peripherally restricted
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1402438-74-7
Sample solution is provided at 25 µL, 10mM.
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Potent and selective pan-Trk inhibitor (IC50 values are 1, 2 and 6 nM for Trk C, B and A, respectively). Selective for Trk over a panel of ion channels, receptors and other enzymes. Peripherally restricted. Exhibits efficacy in a rodent model of inflammatory pain. Orally bioavailable.
Skerratt et al (2016) The discovery of a potent, selective, and peripherally restricted pan-Trk inhibitor (PF-06273340) for the treatment of pain. J.Med.Chem. 59 10084 PMID:27766865
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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