PKUMDL WQ 2201 |
| Catalog No.GC50509 |
Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 592474-91-4
Sample solution is provided at 25 µL, 10mM.
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Negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 35.7 μM). Displays dose-dependent suppression of cell viability in a range of cancer cell lines. Inhibits tumor growth in a xenograft mouse model.
Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID:28042046
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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