Pranoprofen-13C-d3 (Synonyms: Pyranoprofen-13C-d3, Y 8004-13C-d3) |
| Catalog No.GC52270 |
An internal standard for the quantification of pranoprofen
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Pranoprofen-13C-d3 is intended for use as an internal standard for the quantification of pranoprofen by GC- or LC-MS. Pranoprofen is a non-steroidal anti-inflammatory drug (NSAID) and COX-1 inhibitor (IC50 = 3.1 µM).1,2 It decreases B. pertussis-induced production of prostaglandin E2 in isolated rat peritoneal leukocytes (IC50 = 0.39 µM).2 Ocular application of pranoprofen reduces corneal epithelial damage in a mouse model of corneal alkali burns.1
1.Chen, M., Gureeye, A., CissÉ, Y., et al.The therapeutic effects and possible mechanism of pranoprofen in mouse model of corneal alkali burnsJ. Ophthalmol.7485912(2020) 2.Naka, Y., Yamada, I., Ochi, H., et al.Structural optimization of alkyl-substituted 2-(7-5H-[1]benzopyrano[2,3-b]pyridyl)propionic acid as anti-inflammatory agentsBioorg. Med. Chem. Lett.5(9)959-962(1995)
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