PRI-724 |
| Catalog No.GC61205 |
PRI-724 (C-82 prodrug, ICG-001 analog) is a potent and specific inhibitor that disrupts the interaction of β-catenin and CBP.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1422253-38-0
Sample solution is provided at 25 µL, 10mM.
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PRI-724 is a selective inhibitor of the CBP/β-catenin interaction.
PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo. PRI-724 treatment reduces the fibrosis induced by CCl4 or BDL. C-82, an active form of PRI-724, inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs[1].
[1]. Osawa Y, et al. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice. EBioMedicine. 2015 Oct 8;2(11):1751-8.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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