Propafenone-d5 (hydrochloride)

Propafenone-d₅ is intended for use as an internal standard for the quantification of propafenone by GC- or LC-MS. Propafenone is a class I antiarrhythmic agent.¹ It inhibits calcium currents (I_Ca) in isolated guinea pig ventricular myocytes (IC₅₀ = 5 µM), as well as ATP-sensitive potassium currents (IK_ATP) in isolated rabbit atrial and ventricular monocytes (IC₅₀s = 1.26 and 4.94 µM, respectively).^1,2 Propafenone also blocks sodium (I_Na), potassium (I_K), and transient outward potassium currents in various cardiac cells.^2,3,4 In vivo, propafenone (2 and 3 mg/kg, i.v.) reverses sinus rhythm in a dog model of barium chloride-induced ventricular arrhythmia.⁵ Formulations containing propafenone have been used in the treatment of cardiac arrhythmias.

1.Delgado, C., Tamargo, J., D., H., et al.Effects of propafenone on calcium current in guinea-pig ventricular myocytesBr. J. Pharmacol.108(3)721-727(1993) 2.ChristÉ, G., Tebbakh, H., šimurdovÁ, M., et al.Propafenone blocks ATP-sensitive K+ channels in rabbit atrial and ventricular cardiomyocytesEur. J. Pharmacol.373(2-3)223-232(1999) 3.DelpÓn, E., Valenzuela, C.F., PÉrez, O., et al.Propafenone preferentially blocks the rapidly activating component of delayed rectifier K+ current in guinea pig ventricular myocytes. Voltage-independent and time-dependent block of the slowly activating componentCirc. Res.76(2)223-235(1995) 4.Aoyama, K., Ishikuro, E., Noriduki, H., et al.Formation ratios of zearalanone, zearalenols, and zearalanols versus zearalenone during incubation of Fusarium semitectum on sorghum and ratios in naturally contaminated sorghumFood Hyg. Saf. Sci.56(6)247-251(2015) 5.Germiniani, H., and Germiniani, C.Effect of propafenone hydrochloride in ventricular arrhythmias experimentally induced by barium chlorideArq. Bras. Cardiol.36(2)101-105(1981)