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PSB-1584

Catalog No.GB40333

GPR84 is an orphan G protein-coupled receptor that is activated by medium-chain fatty acids and hydroxy fatty acids although these may not be its endogenous agonist. 

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PSB-1584 Chemical Structure

Cas No.: 72255-76-6

Size Price Stock Qty
5mg
$180.00
In stock
25mg
$660.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

GPR84 is an orphan G protein-coupled receptor that is activated by medium-chain fatty acids and hydroxy fatty acids although these may not be its endogenous agonist. It is highly expressed on immune cells and expression levels rise after exposure to inflammatory stimuli. Potent synthetic agonists enhance proinflammatory signaling and macrophage effector functions. PSB-1584 is a potent synthetic exogenous agonist at GPR84, EC50=5 nM which is selective against other free fatty acid receptors and is metabolically stable when incubated with human liver microsomes. An important new tool for studying the physiology of GPR84.

Chemical Properties

Cas No. 72255-76-6 SDF Download SDF
Formula C10H17N3O2 M.Wt 211.26
Solubility Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 4.7335 mL 23.6675 mL 47.335 mL
5 mM 0.9467 mL 4.7335 mL 9.467 mL
10 mM 0.4734 mL 2.3668 mL 4.7335 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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