Home>>Modified Nucleotides>>Pseudo-UTP,100mM Tris Solution

Pseudo-UTP,100mM Tris Solution

Catalog No.GB20003

Pseudo-UTP,100mM Tris Solution Chemical Structure

A modified nucleoside-5’-O-triphosphate, commonly used for drugable mRNA synthesis

Size Price Stock Qty
10ul
$40.00
In stock
50ul
$120.00
In stock
100ul
$180.00
In stock
1mL
$650.00
In stock
10mL Please Inquire Please Inquire
100mL Please Inquire Please Inquire
500mL Please Inquire Please Inquire

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Sample solution is provided at 25 µL, 10mM.

Background

Pseudo-UTP, also known as pseudouridine-5’-O-triphosphate, is one of the most commonly used modified nucleoside-5’-O-triphosphates. Pseudo-UTP is a building block for the polymerase-mediated synthesis of RNA molecules. RNA molecules, especially messenger RNAs (mRNAs), have widespread applications in therapeutic and diagnostic areas, and have demonstrated their superiority over plasmid DNA techniques in both gene and vaccination therapy. Compared with uridine-containing unmodified mRNAs, the application of pseudouridine-containing modified mRNAs exhibits better nuclease stability, immunogenicity, and translational properties. Thus, pseudo-UTP could be used to develop drugable mRNAs with improved properties, by replacing the standard bases by modified ones.

Chemical Properties

Cas No. N/A SDF N/A
Synonyms Pseudouridine-5'-Triphosphate, 5-Ribosyl Uracil
Chemical Name N/A
Canonical SMILES O=C(NC=C1C2C(O)C(O)C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)O2)NC1=O.[Li+].[Li+].[Li+].[Li+]
Formula C9H15N2O15P3(freeacid) M.Wt 484.10(freeacid)
Solubility N/A Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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