PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt) (Synonyms: DHPI-3,4,5-P3, Phosphatidylinositol-3,4,5-triphosphate C-6, PIP3C-16) |
Catalog No.GC44748 |
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 799268-62-5
Sample solution is provided at 25 µL, 10mM.
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3, also known as PIP3, is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. PIP3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking. PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) is a synthetic analog of natural PIP3 with C6:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacylglycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this analog give it different physical properties from naturally-occurring PIP3, including higher solubility in aqueous media.
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(Based on Reviews and 22 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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