Cytochalasin A (Synonyms: Dehydrophomin, NSC 174119, Phomin) |
| Catalog No.GC43358 |
The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization.
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Cas No.: 14110-64-6
Sample solution is provided at 25 µL, 10mM.
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The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-1 protease (IC50 = 3 μM). Cytochalasins A and B differ from other cytochalasins in being able to rapidly and reversibly inhibit glucose transport by competitively binding glucose transporters (Ki = 4.0 and 0.6 μM, respectively). Cytochalasin A also induces the phosphorylation of the tyrosine phosphatase PTP3 of Dictyostelium, activating STATc.
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