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Home >> Signaling Pathways >> Others >> Mineralocorticoid Receptor

Mineralocorticoid Receptor

The mineralocorticoid receptor is a nuclear hormone receptor for aldosterone and glucocorticoids. It acts as a transcription factor to regulate the water-salt homeostasis and blood pressure in the target cell. It also plays physiological roles in kidney, brain and cardiovascular system.

Products for  Mineralocorticoid Receptor

  1. Cat.No. Product Name Information
  2. GC62332 (Rac)-Finerenone

    (Rac)-BAY 94-8862

     (Rac)-Finerenone ((Rac)-BAY 94-8862) is the racemate of Finerenone. (Rac)-Finerenone Chemical Structure
  3. GC64594 (S)-Baxdrostat (S)-Baxdrostat is the S-enantiomer of Baxdrostat. (S)-Baxdrostat Chemical Structure
  4. GC62759 18-Oxocortisol 18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol Chemical Structure
  5. GC31448 Apararenone (MT-3995)

    MT-3995

     Apararenone (MT-3995) (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis. Apararenone (MT-3995) Chemical Structure
  6. GC62386 AZD9977

    AZD9977

     AZD9977 is a potent, selective, and orally active mineralocorticoid receptor (MR) modulator. AZD9977 Chemical Structure
  7. GC64593 Baxdrostat Baxdrostat is a aldosterone synthase inhibitor. Baxdrostat Chemical Structure
  8. GC17537 Canrenone

    Aldadiene, NSC 261713, SC-9376, SC-14266

     Mineralocorticoid receptor antagonist Canrenone Chemical Structure
  9. GC12349 Deoxycorticosterone acetate

    DOCA

     Steroid hormone Deoxycorticosterone acetate Chemical Structure
  10. GC35862 Dicirenone Dicirenone (SC26304) inhibits the effects of Aldosterone on urinary K+:Na+ ratios and the binding of [3H]Aldosterone to renal cytoplasmic and nuclear receptors. Dicirenone Chemical Structure
  11. GC15831 Eplerenone

    CGP 30083, (+)-Eplerenone, Epoxymexrenone, SC-6110, SC-66110

     Eplerenone is an orally active mineralocorticoid receptor (MR) antagonist that blocks the effects of aldosterone, with an IC50 value of 0.081μM. Eplerenone Chemical Structure
  12. GC19143 Esaxerenone Esaxerenone (CS-3150), a selective nonsteroidal mineralocorticoid receptor antagonist, has been shown to bind to mineralocorticoid receptors, thereby inhibiting aldosterone binding and activation of the receptor. Esaxerenone Chemical Structure
  13. GC31789 Fludrocortisone (9α-Fludrocortisone)

    Astonin-H, 9α-Fludrocortisone, Fluohydrocortisone, Fluorohydrocortisone, NSC 11318

     Fludrocortisone (9α-Fludrocortisone), a synthetic mineralocorticoid with anti-inflammatory activity. Fludrocortisone (9α-Fludrocortisone) Chemical Structure
  14. GC33848 Fludrocortisone acetate (9α-Fludrocortisone acetate)

    9α-fluoro Hydrocortisone Acetate, NSC 15186, U 4845

     Fludrocortisone acetate (9α-Fludrocortisone acetate) (9α-Fludrocortisone acetate (9α-Fludrocortisone acetate)) is a synthetic mineralocorticoid, used to control the amount of sodium and fluids in your body. Fludrocortisone acetate (9α-Fludrocortisone acetate) Chemical Structure
  15. GC69397 Lorundrostat

    Lorundrostat is an aldosterone synthase inhibitor.

     Lorundrostat Chemical Structure
  16. GC65465 Ocedurenone Ocedurenone is a corticosteroid receptor antagonist. Ocedurenone Chemical Structure
  17. GC19273 Osilodrostat

    LCI699

     Osilodrostat (LCI699) is a potent inhibitor of human 11β-hydroxylase and aldosterone synthase with IC50 values of 2.5 and 0.7 nM, respectively. Osilodrostat Chemical Structure
  18. GC66454 Osilodrostat phosphate

    LCI699 phosphate

     Osilodrostat (LCI699) phosphate is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat phosphate is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat phosphate inhibits aldosterone and corticosterone synthesis. Osilodrostat phosphate has blood pressure lowering ability. Osilodrostat phosphate can be used for research of Cushing syndrome (CS). Osilodrostat phosphate Chemical Structure
  19. GC17090 RU 28318, potassium salt RU 28318, potassium salt is a potent mineralocorticoid (MR) antagonist. RU 28318, potassium salt Chemical Structure
  20. GC39564 Vamorolone Vamorolone (VBP15) is a first-in-class, orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone Chemical Structure

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