NADPH Oxidase
NADPH oxidase (NOX) is a transmembrane enzyme that is located in intracellular organelles. NADPH oxidase (NOX) enzymes are membrane-bound proteins that catalyze the conversion of oxygen to superoxide. There are a number of isoforms, NOX1-5 and dual oxidases 1 and 2 (DUOX1-2), which have diverse functions. NOX1, NOX2, NOX4, and NOX5 are expressed in human vascular tissue. NOX1 and NOX2 are regulated by cytosolic components loosely termed as activators or organizers, which are generally recruited to the membrane components following cellular stimuli to assemble an active NOX. Molecular switch from NOX1 to NOX2 in colon cancer cells induces ROS production and subsequently enhances MMP-7 expression by deactivating AMPK. Vascular NOX4 is a multifarious NADPH oxidase. NOX4 is a hydrogen peroxide-generating oxygen sensor.
Products for NADPH Oxidase
- Cat.No. Product Name Information
- GC38353 APX-115 APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively.
- GC38115 APX-115 free base APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively.
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GC12520
Diphenyleneiodonium chloride
Diphenyleneiodonium (DPI) chloride (DPIC), as a NADH/NADPH oxidase inhibitor, has possessing potent antimicrobial activity against Mtb and S. aureus.
- GC62989 GKT136901 hydrochloride GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively.
- GC11882 GKT137831 GKT137831 (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively.
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GC31367
GLX351322
A NOX4 inhibitor
- GC32681 GSK2795039 A NOX2 inhibitor
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GC12291
ML 171
NADPH oxidase 1 (NOX1) inhibitor
- GC12323 ML-090 ML-090 (ML-090) is a selective NOX1 inhibitor with an IC50of 90 nM.
- GC50281 NoxA1ds Potent and selective NADPH oxidase 1 (NOX1) inhibitor
- GC63986 VAS 3947
- GC32443 VAS2870 A pan-NADPH oxidase inhibitor