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Home >> Signaling Pathways >> Others >> NADPH Oxidase

NADPH Oxidase

NADPH oxidase (NOX) is a transmembrane enzyme that is located in intracellular organelles. NADPH oxidase (NOX) enzymes are membrane-bound proteins that catalyze the conversion of oxygen to superoxide. There are a number of isoforms, NOX1-5 and dual oxidases 1 and 2 (DUOX1-2), which have diverse functions. NOX1, NOX2, NOX4, and NOX5 are expressed in human vascular tissue. NOX1 and NOX2 are regulated by cytosolic components loosely termed as activators or organizers, which are generally recruited to the membrane components following cellular stimuli to assemble an active NOX. Molecular switch from NOX1 to NOX2 in colon cancer cells induces ROS production and subsequently enhances MMP-7 expression by deactivating AMPK. Vascular NOX4 is a multifarious NADPH oxidase. NOX4 is a hydrogen peroxide-generating oxygen sensor.

Products for  NADPH Oxidase

  1. Cat.No. Product Name Information
  2. GC38353 APX-115

    Ewha-18278

     APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 Chemical Structure
  3. GC38115 APX-115 free base

    Ewha-18278 free base

     APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base Chemical Structure
  4. GC12520 Diphenyleneiodonium chloride

    DPI

     Diphenyleneiodonium (DPI) chloride (DPIC), as a NADH/NADPH oxidase inhibitor, has possessing potent antimicrobial activity against Mtb and S. Diphenyleneiodonium chloride Chemical Structure
  5. GC62989 GKT136901 hydrochloride GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride Chemical Structure
  6. GC11882 GKT137831 GKT137831 (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively. GKT137831 Chemical Structure
  7. GC31367 GLX351322

    A NOX4 inhibitor

     GLX351322 Chemical Structure
  8. GC71289 GLX481304 GLX481304 is a specific inhibitor of Nox-2 and -4, with IC50s of 1.25 μM. GLX481304 Chemical Structure
  9. GC32681 GSK2795039 A NOX2 inhibitor GSK2795039 Chemical Structure
  10. GC12291 ML 171

    2-APT, ML-171, NSC 57951, NSC 169669

    NADPH oxidase 1 (NOX1) inhibitor

     ML 171 Chemical Structure
  11. GC12323 ML-090

    CCG-44699,CID-616479,Fluoflavin,NSC 179821

     ML-090 (ML-090) is a selective NOX1 inhibitor with an IC50of 90 nM. ML-090 Chemical Structure
  12. GC71188 NADPH oxidase-IN-1 NADPH oxidase-IN-1 is an orally active NADPH oxidase (Nox) inhibitor, related with neuronal inflammation. NADPH oxidase-IN-1 Chemical Structure
  13. GC50281 NoxA1ds Potent and selective NADPH oxidase 1 (NOX1) inhibitor NoxA1ds Chemical Structure
  14. GC63986 VAS 3947 VAS 3947 Chemical Structure
  15. GC32443 VAS2870 A pan-NADPH oxidase inhibitor VAS2870 Chemical Structure

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