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Enterovirus

Human rhinoviruses (HRVs) and enteroviruses (HEVs) belong to the Picornaviridae family and are prominent causes of respiratory disease. They share identical genomic organization and high sequence homology. Their genome is divided into three sections: a 5’untranslated region (5’UTR), an open reading frame of the polyprotein that codes for all four capsid proteins (VP1-4) and the non-structural genes, and a 3’untranslated region.

Enteroviruses are members of the picornavirus family, a large and diverse group of small RNA viruses. According to the present classification, the enterovirus genus comprises the following species: poliovirus, human enterovirus A (HEV-A) (coxackie A viruses and enterovirus 71), HEV-B (coxsackie B viruses, echoviruses, coxsackie A9 virus, and enteroviruses 69 and 73), HEV-C (coxsackie A viruses), HEV-D (enteroviruses 68 and 70), and at least three animal enterovirus species (bovine, simian, and porcine enteroviruses). They all contain a genome of approximately 7,500 bases and positive [(+)]-strand polarity. After infection of the host cell, the genome is translated in a cap-independent manner into a single polyprotein, which is subsequently processed by virus-encoded proteases into the structural capsid proteins and the nonstructural proteins, which are mainly involved in the replication of the virus.

Targets for  Enterovirus

Products for  Enterovirus

  1. Cat.No. Product Name Information
  2. GC39353 Brilliant Black BN A sulfonated azo dye with antiviral activity Brilliant Black BN  Chemical Structure
  3. GC60099 Carbocisteine Carbocisteine, a mucolytic agent, can be used for the research of chronic obstructive pulmonary disease (COPD). Carbocisteine  Chemical Structure
  4. GC41462 cis-Resveratrol

    Resveratrol is a potent phenolic antioxidant found in grapes, red wine, and various berries that also has antiproliferative and anti-inflammatory activity.

    cis-Resveratrol  Chemical Structure
  5. GC64636 DMA-135 hydrochloride DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride  Chemical Structure
  6. GC18620 EIDD-1931

    A ribonucleoside analog with antiviral activity

    EIDD-1931  Chemical Structure
  7. GC38050 Hederasaponin B A triterpene saponin with antiviral and antioxidant activities Hederasaponin B  Chemical Structure
  8. GC39097 Mosloflavone Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with ?anti-EV71 activity. Mosloflavone  Chemical Structure
  9. GC61956 NHC-diphosphate NHC-diphosphate is an active phosphorylated?intracellular metabolite?of β-d-N4-Hydroxycytidine (NHC) as a diphosphate form. NHC-diphosphate  Chemical Structure
  10. GC61130 NHC-triphosphate

    NHC-triphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form.

    NHC-triphosphate  Chemical Structure
  11. GC61961 NHC-triphosphate tetrasodium NHC-triphosphate tetrasodium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form. NHC-triphosphate tetrasodium  Chemical Structure
  12. GC45990 Norwogonin A polyhydroxy flavone with diverse biological activities Norwogonin  Chemical Structure
  13. GC17737 PD 169316 P38 MAPK inhibitor PD 169316  Chemical Structure
  14. GC19296 Pirodavir Pirodavir is a potent, broad-spectrum picornavirus inhibitor, and is highly active against both group A and group B rhinovirus serotypes. Pirodavir  Chemical Structure
  15. GC32067 Pleconaril (VP 63843) Pleconaril (VP 63843) is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril (VP 63843)  Chemical Structure
  16. GC32120 Pocapavir (SCH-48973) Pocapavir (SCH-48973) (SCH-48973) is an orally active capsid inhibitor. Pocapavir (SCH-48973)  Chemical Structure
  17. GC39066 Prunin A flavonoid glycoside with diverse biological activities Prunin  Chemical Structure
  18. GC50441 Rupintrivir Potent and selective irreversible human rhinovirus 3C protease inhibitor Rupintrivir  Chemical Structure
  19. GC61359 TTP-8307 TTP-8307 is a potent inhibitor of the replication of several rhino- and enteroviruses. TTP-8307  Chemical Structure
  20. GC48241 Vapendavir A capsid-binding antiviral agent Vapendavir  Chemical Structure
  21. GC63291 WIN 54954 WIN 54954 is an orally active and broad-spectrum antipicornavirus agent. WIN 54954  Chemical Structure

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