SRPK

SRPK (serine/arginine-rich protein-specific kinases) specifically phosphorylate their substrate at serine residues in RS domain. It functions in SR splicing factors phosphorylation and splicing regulation. It is involvd in regulation of HBV replication, neuronal apoptosis and muscle development etc.

Products for SRPK

Cat.No. Product Name Information
GC69507 MSC-1186
MSC-1186 is a highly selective pan-SRPK inhibitor. It has activity against SRPK1, SRPK2, and SRPK3 with IC50 values of 2.7 nM, 81 nM, and 0.6 nM respectively. MSC-1186 can be used for cancer research.
GC65981 SPHINX SPHINX is a selective SRPK1 inhibitor with an IC50 value of 0.58 μM. SPHINX effectively reduces Choroidal Neovascularization (CNV) in vivo. SPHINX can be used for the research of (age-related macular degenaration) AMD.
GC19456 SPHINX31 A potent inhibitor of SRPK1
GC13596 SRPIN340

SRPK Inhibitor
Selective SRPK1 inhibitor
GC72856 SRPIN803 SRPIN803 is a potent CK2 and SRPK1 dual inhibitor, with IC50s of 203 nM and 2.4 μM, respectively.
GC32583 SRPKIN-1 SRPKIN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively.