S-(2-aminoethyl) Isothiourea (dihydrobromide) (Synonyms: Antiradon,NSC 22877) |
| Catalog No.GC11745 |
non-selective inhibitor of all NOS isoforms
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 56-10-0
Sample solution is provided at 25 µL, 10mM.
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S-(2-aminoethyl) Isothiourea (dihydrobromide) is a potent and non-selective inhibitor of NOS with Ki values of 1.8, 2.1, and 0.59 μM for human nNOS, eNOS, and iNOS, respectively [1].
In the brain, nitric oxide (NO), which is synthesized from L-arginine (Arg) by NO synthase (NOS), acts as both an intra- and an intercellular second messenger. Nitric oxide synthase (iNOS, eNOS, and nNOS) catalyzed the production of NO in the two-step oxidation of L-arginine. The three isozymes produce NO in separate tissues for different purposes in both normal and diseased states [1].
S-(2-aminoethyl) Isothiourea is a potent and non-selective NOS inhibitor with Ki values of 1.8, 2.1, and 0.59 μM for human nNOS, eNOS, and iNOS, respectively [1].
Reference:
[1]. Garvey EP, Oplinger JA, Tanoury GJ, et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem. 1994 Oct 28;269(43):26669-76.
| Cas No. | 56-10-0 | SDF | |
| Synonyms | Antiradon,NSC 22877 | ||
| Chemical Name | 2-aminoethyl carbamimidothioate, dihydrobromide | ||
| Canonical SMILES | N/C(SCCN)=N/[H].Br.Br | ||
| Formula | C3H9N3S · 2HBr | M.Wt | 281 |
| Solubility | ≤10mg/ml in Water | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.5587 mL | 17.7936 mL | 35.5872 mL |
| 5 mM | 0.7117 mL | 3.5587 mL | 7.1174 mL |
| 10 mM | 0.3559 mL | 1.7794 mL | 3.5587 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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