S3QEL-2 |
| Catalog No.GC44862 |
S3QEL-2 is a cell-permeable, selective suppressor of electron leak from mitochondrial respiratory complex III, inhibiting site IIIQo superoxide production (IC50 = 1.7 μM) without altering normal bioenergetics function.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 890888-12-7
Sample solution is provided at 25 µL, 10mM.
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S3QEL-2 is a cell-permeable, selective suppressor of electron leak from mitochondrial respiratory complex III, inhibiting site IIIQo superoxide production (IC50 = 1.7 µM) without altering normal bioenergetics function.[1] It reduces production of H2O2 during oxidation of glutamate plus malate to 25% of the control level. S3QEL-2 also protects against ROS-induced cell stress in pancreatic β-cells and decreases HIF-1α induction in response to hypoxia.
Reference:
[1]. Orr, A.L., Vargas, L., Turk, C.N., et al. Suppressors of superoxide production from mitochondrial complex III. Nat. Chem. Biol. 11, 834-840 (2015).
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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