Salazinic Acid (Synonyms: NSC 87509) |
| Catalog No.GC46216 |
A depsidone lichen metabolite
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 521-39-1
Sample solution is provided at 25 µL, 10mM.
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Salazinic acid is a depsidone lichen metabolite that has been found in P. sulcata.1 It is active against B. cereus, B. subtilis, S. aureus, P. aeruginosa, S. typhimurium, C. albicans, and A. niger in vitro (MICs = 3.9-30.8 mM). Salazinic acid is cytotoxic to MM98, A431, and HaCaT cells in crystal violet (EC50s = 159, 2,870, and 48 μM, respectively) and neutral red uptake assays (EC50s = 1,925, 1,913, and 907 μM, respectively).2 It increases the wound closure rate in scratch-wounded HaCaT monolayers and increases HaCaT cell migration in a transwell assay when used at a concentration of 30 μM.
|1. Candan, M., Yilmaz, M., Tay, T., et al. Antimicrobial activity of extracts of the lichen Parmelia sulcata and its salazinic acid constituent. Z. Naturforsch. C J. Biosci. 62(7-8), 619-621 (2007).|2. Burlando, B., Ranzato, E., Volante, A., et al. Antiproliferative effects on tumour cells and promotion of keratinocyte wound healing by different lichen compounds. Planta. Med. 75(6), 607-613 (2009).
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