Sim-9 |
Catalog No.GC79380
One-Click Copy Product Info
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Sim-9 is a covalent allosteric inhibitor of interferon regulatory factor 3 ( IRF3 ).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3099101-40-0
Sample solution is provided at 25 µL, 10mM.
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In Vivo, Sim-9 (30-60 mg/kg; i.p.; single injection) exhibits protective and anti-inflammatory activities in a mouse sepsis model[1]. Sim-9 (30-60 mg/kg; i.p.; 1 injection/3 injections) improves pancreatic edema and the levels of inflammatory markers in a mouse model of acute pancreatitis[1].
In Vitro, Sim-9 (2.5-10 μM) dose-dependently inhibits interferon responses induced by TLRs/RLRs/STING activation in murine RAW264.7 cells and human THP-1/HT-29/A549 cells[1]. Sim-9 (5 μM; 0.5-6 h) inhibits the phosphorylation of IRF3 in mouse RAW264.7 cells activated via the cGAS-STING, TLR3 or RIG-I pathways, without altering the phosphorylation of TBK1[1]. Sim-9 (5 μM) inhibits the homodimerization of IRF3 in mouse RAW264.7 cells activated via the cGAS-STING, TLR3 or RIG-I pathways[1].
References:
[1]. Li S, et al. A sinomenine derivative protects life-threatening inflammatory injuries via covalently binding to a novel allosteric inhibition site of IRF3. Acta Pharmacol Sin. Published online January 16, 2026.
| Cas No. | 3099101-40-0 | SDF | |
| Formula | C31H28F3NO6 | M.Wt | 567.55 |
| Solubility | DMSO: ≥ 100 mg/mL (176.20 mM) | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.762 mL | 8.8098 mL | 17.6196 mL |
| 5 mM | 352.4 μL | 1.762 mL | 3.5239 mL |
| 10 mM | 176.2 μL | 881 μL | 1.762 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)