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Home >> Signaling Pathways >> Immunology/Inflammation >> IFNAR

IFNAR

The interferon-α/β receptor (IFNAR) is a receptor which binds type I interferons including interferon-α and -β. It is a heteromeric cell surface receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2. Upon binding of type I IFNs, IFNAR activates the JAK-STAT signaling pathway. Interferon stimulation classically results in an anti-viral immune response. Type I IFNs share a common receptor consisting of two subunits, IFNAR1 and IFNAR2, which associate upon IFN binding. IFNAR2 is the major ligand binding component of the receptor complex, exhibiting nanomolar affinity to both IFNα and IFNβ subtypes. IFNAR1 and IFNAR2 belong to the class II helical cytokine receptor (hCR) family, which includes the receptor for type II IFN, tissue factor (TF), and IL10Rβ.

Targets for  IFNAR

Products for  IFNAR

  1. Cat.No. Product Name Information
  2. GC19989 2',3'-cGAMP

    2'-3'-cyclic GMP-AMP

     2',3'-cGAMP is a specific agonist of the STING receptor, and its mechanism of action primarily involves activating the STING signaling pathway, promoting the production of interferons and inflammatory cytokines. 2',3'-cGAMP Chemical Structure
  3. GC39324 2',3'-cGAMP sodium

    2'-3'-cyclic GMP-AMP sodium

     2′3′-cGAMP sodium is a second messenger that binds and activates the adaptor protein stimulator of interferon (STING), which triggers the innate immune response. 2',3'-cGAMP sodium Chemical Structure
  4. GC79397 2'2'-cGAMP disodium 2'2'-cGAMP disodium, a synthetic CDN, binds STING in the immune response, inducing IFN-β. 2'2'-cGAMP disodium binds weaker binding to STING than 2'3'-cGAMP but stronger than other CDNs [1]. 2'2'-cGAMP disodium Chemical Structure
  5. GA20643 Ac-Pro-Gly-Pro-OH Ac-Pro-Gly-Pro-OH is an endogenous degradation product of extracellular collagen and acts as a CXCR2 agonist. Ac-Pro-Gly-Pro-OH Chemical Structure
  6. GC79067 ADAR1i-124 ADAR1i-124 is an A-to-I RNA editing inhibitor by inhibiting the catalytic activities of both ADAR1p150 and ADAR1p110. ADAR1i-124 Chemical Structure
  7. GC79708 Alcudacigib TFA

    DGKζ-IN-1 TFA

     Alcudacigib (ASP1570; DGKζ-IN-1) TFA is an orally active diacylglycerol kinase ζ ( DGKζ ) inhibitor, with an IC50 of 4.7 nM against human DGKζ and an IC50 of 3.0 nM against mouse DGKζ. Alcudacigib TFA selectively inhibits the kinase activity of DGKζ and induces proteasome-dependent degradation of DGKζ protein. Alcudacigib TFA Chemical Structure
  8. GC79339 Anti-CD160 Antibody (MAT 302)

    CL1-R2

     Anti-CD160 Antibody (MAT 302) (CL1-R2) is a human monoclonal antibody targeting CD160. Anti-CD160 Antibody (MAT 302) Chemical Structure
  9. GC79379 Anti-Mouse IFN Beta Antibody (MIB-5E9.1) Anti-Mouse IFN Beta Antibody (MIB-5E9.1) is an antibody targeting mouse IFN-β. Anti-Mouse IFN Beta Antibody (MIB-5E9.1) blocks the IFN-β signaling pathway, abolishes LPS-induced upregulation of B7H1 and GITRL in dendritic cells, restores dendritic cell-dependent T cell proliferation impaired by LPS exposure, and reverses LPS-induced upregulation of PD-1 on splenic T cells. Anti-Mouse IFN Beta Antibody (MIB-5E9.1) Chemical Structure
  10. GC79340 Anti-Mouse TREM2 Antibody (178) Anti-Mouse TREM2 Antibody (178) is an antibody targeting mouse TREM2, which blocks the binding of ligands to TREM2 and inhibits TREM2 -mediated signaling pathways. Anti-Mouse TREM2 Antibody (178) Chemical Structure
  11. GC35440 AX-024 AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 Chemical Structure
  12. GC19046 AX-024 hydrochloride AX-024 hydrochloride is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A. AX-024 hydrochloride Chemical Structure
  13. GC14727 CCCP

    Carbonyl cyanide m-chlorophenyl hydrazone, NSC 88124

     CCCP isa protonophore altering the permeability of mitochondria inner membrane to protons. CCCP Chemical Structure
  14. GC63591 Cirsilineol Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4+ T cells. Cirsilineol Chemical Structure
  15. GC38648 Cridanimod Cridanimod is a potent progesterone receptor (PR) activator mediated through induction of IFNα and IFNβ expression. Cridanimod Chemical Structure
  16. GC65545 Cyclo(L-Phe-L-Pro) Cyclo(L-Phe-L-Pro) Chemical Structure
  17. GC72324 Dazukibart Dazukibart is a mouse-derived, humanized IgG1κ antibody targeting interferon beta 1 (IFNB1). Dazukibart Chemical Structure
  18. GC72791 Delmitide acetate

    RDP-58 acetate

     Delmitide (RDP58) acetate is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide acetate Chemical Structure
  19. GC80940 dIRF4-2 dIRF4-2 is a selective IRF4 PROTAC degrader with a DC50 value of 2.2 μM. dIRF4-2 Chemical Structure
  20. GC69056 Emapalumab

    NI-0501

    Emapalumab (NI-0501) is a humanized IgG1 monoclonal antibody that can non-competitively inhibit IFN-γ. Emapalumab has high affinity (Kd=1.4 pM) for both free IFN-γ and IFN-γ bound to its receptor. Emapalumab can be used in the study of hemophagocytic lymphohistiocytosis (HLH).

     Emapalumab Chemical Structure
  21. GC79440 ENDO12 ENDO12 is an inhibitor of the Munc13-4-STX7 protein complex, with a K d value of 2.7 µM for STX7. ENDO12 Chemical Structure
  22. GC69093 Faralimomab

    64G12

    Faralimomab (64G12) is an immunomodulatory agent and a mouse anti-IFNA1 IgG1 monoclonal antibody.

     Faralimomab Chemical Structure
  23. GC72352 Fontolizumab Fontolizumab (HuZAF) is a humanized monoclonal anti-IFN-gamma antibody. Fontolizumab Chemical Structure
  24. GC79375 Frenlosirsen

    ION-935918; ION251

     Frenlosirsen (ION-935918; ION251) is an antisense oligonucleotide and also an IRF4 inhibitor. Frenlosirsen Chemical Structure
  25. GC79376 Frenlosirsen scrambled control Frenlosirsen scrambled control is a scrambled control antisense oligonucleotide of Frenlosirsen with a scrambled sequence in the target binding region. Frenlosirsen scrambled control Chemical Structure
  26. GC79377 Frenlosirsen sodium

    ION-935918 sodium; ION251 sodium

     Frenlosirsen sodium (ION-935918 sodium; ION251 sodium) is an antisense oligonucleotide and also an IRF4 inhibitor. Frenlosirsen sodium Chemical Structure
  27. GC74077 HEI3090 HEI3090 is a P2X7R activator. HEI3090 Chemical Structure
  28. GC79428 Icotrokinra acetate

    JNJ-77242113 acetate; JNJ-2113 acetate; PN-235 acetate

     Icotrokinra (JNJ-77242113) acetate is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra acetate Chemical Structure
  29. GC79429 Icotrokinra hydrochloride

    JNJ-77242113 hydrochloride; JNJ-2113 hydrochloride; PN-235 hydrochloride

     Icotrokinra (JNJ-77242113) hydrochloride is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra hydrochloride Chemical Structure
  30. GC31799 IFN alpha-IFNAR-IN-1 (IFN-alpha and IFNAR interaction inhibitor) IFN alpha-IFNAR-IN-1 (IFN-alpha and IFNAR interaction inhibitor) is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM). IFN alpha-IFNAR-IN-1 (IFN-alpha and IFNAR interaction inhibitor) Chemical Structure
  31. GC60927 IFN alpha-IFNAR-IN-1 hydrochloride An inhibitor of the IFN-α-IFNAR protein-protein interaction IFN alpha-IFNAR-IN-1 hydrochloride Chemical Structure
  32. GC34307 IFN alpha-IFNAR-IN-1 hydrochloride (IFN-alpha and IFNAR interaction inhibitor) IFN alpha-IFNAR-IN-1 hydrochloride (IFN-alpha and IFNAR interaction inhibitor) Chemical Structure
  33. GC36296 IFN-α Receptor Recognition Peptide 1

    IRRP1

     IFN-α Receptor Recognition Peptide 1 is a peptide of IFN-α associated with receptor interactions. IFN-α Receptor Recognition Peptide 1 Chemical Structure
  34. GC69259 IFN-γ Antagonist 1 acetate

    IFN-β Antagonist 1 (AYCRDGKIGPPKLDIRKEEKQI) acetate is an interferon β (IFN-β) antagonist. IFN-β Antagonist 1 inhibits the expression of HLR/DR antigens induced by IFN-β in Colo 205 cells, with an IC50 value of approximately 35 μM. IFN-β Antagonist 1 has potential applications in immunoregulation.

     IFN-γ Antagonist 1 acetate Chemical Structure
  35. GC79426 IFN-α Receptor Recognition Peptide 1 acetate

    IRRP1 acetate

     IFN-α Receptor Recognition Peptide 1 acetate (IRRP1 acetate) is an amino acid synthetic peptide and also a regulator of IFN-α Receptor. IFN-α Receptor Recognition Peptide 1 acetate Chemical Structure
  36. GC32019 Interferon receptor agonist Interferon receptor agonist (compound 6) is an interferon (IFN) receptor inducer. Interferon receptor agonist Chemical Structure
  37. GC80942 IRF4 ligand-1 IRF4 ligand-1 is an IRF4 ligand that can be used for the synthesis of PROTACs, such as dIRF4-2 [1]. IRF4 ligand-1 Chemical Structure
  38. GC79056 KMR-206 KMR-206 is a PARP7 inhibitor with an IC50 of 13.7 nM. KMR-206 Chemical Structure
  39. GC65435 Monalizumab

    Monalizumab is a first-in-class immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A).

     Monalizumab Chemical Structure
  40. GC68293 ODN 1585 ODN 1585 Chemical Structure
  41. GC73317 ODN 1585 sodium ODN 1585 is a potent inducer of IFN and TNFα production. ODN 1585 sodium Chemical Structure
  42. GC69613 ODN 6016

    ODN 6016 is a type of CpG-A oligonucleotide. ODN 6016 can induce the production of IFN-α and can be used to study immune disorders, including those caused by HIV-1. The sequence of ODN 6016 is T-sp-C-G-A-C-G-T-C-G-T-G-G-sp-G-sp-G-sp-G.

     ODN 6016 Chemical Structure
  43. GC69615 ODN D-SL03

    ODN D-SL03 is a type of Class C CpG oligonucleotide that can induce high levels of IFN-α production in PBMCs. ODN D-SL03 can activate human B cells, NK cells, and monocytes, upregulating the expression of CD80, CD86, and HLA-DR on subsets of human PBMCs. ODN D-SL03 also has the ability to inhibit tumor growth. The sequence for ODN D-SL03 is 5'-tcgcgaacgttcgccgcgttcgaacgcgg-3'.

     ODN D-SL03 Chemical Structure
  44. GC73326 ODN D-SL03 sodium ODN D-SL03 sodium is a C class CpG oligonucleotides, and can induce stimulate PBMCs to produce high level of IFN-α. ODN D-SL03 sodium Chemical Structure
  45. GC81314 OM-RCA-01 OM-RCA-01 is an anti- FGFR1 monoclonal antibody with a K d of 1.59 nM for human FGFR1. OM-RCA-01 Chemical Structure
  46. GC79378 Peginterferon alfa-2a

    Ro 25-8310/000

     Peginterferon alfa-2a (Ro 25-8310/000) is a 40 kDa branched pegylated IFN alfa-2a with antiviral and immunomodulatory activities. Peginterferon alfa-2a Chemical Structure
  47. GC81322 PF-07245303 PF-07245303 is a ITK / TRK inhibitor. PF-07245303 Chemical Structure
  48. GC78901 PTD-N5-1 acetate PTD-N5-1 acetate is an IRF5 inhibitory peptide. PTD-N5-1 acetate Chemical Structure
  49. GC79372 Rosnilimab (Mouse IgG2a) Rosnilimab (Mouse IgG2a ) is a mouse-derived IgG2a antibody, Rosnilimab. Rosnilimab (Mouse IgG2a) Chemical Structure
  50. GC69889 Sifalimumab

    MEDI-545; MDX 1103

    Sifalimumab (MEDI-545) is a monoclonal antibody that targets and inhibits abnormal immune activity by binding to multiple subtypes of interferon-alpha. It can be used for research on systemic lupus erythematosus (SLE).

     Sifalimumab Chemical Structure
  51. GC79380 Sim-9 Sim-9 is a covalent allosteric inhibitor of interferon regulatory factor 3 ( IRF3 ). Sim-9 Chemical Structure
  52. GC79277 Solaprubart

    STAR-0310

     Solaprubart (STAR-0310) is a fully human IgG1 subtype monoclonal antibody targeting OX40 (CD134/TNFRSF4), with a K d of 7.2 nM. Solaprubart Chemical Structure
  53. GC79707 ST1072 ST1072 is an inhibitor of CerS4 and CerS6. ST1072 Chemical Structure
  54. GC78685 STING-IN-15 STING-IN-15 is a potent STING inhibitor with an IC50 value of 116nM. STING-IN-15 Chemical Structure

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