Somatostatin-28 (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

Somatostatin-28 is a cyclic neuropeptide hormone that has a role in endocrine regulation.¹ It is a somatostatin (SST) receptor agonist that binds to SST₁, SST₂, SST₃, SST₄, and SST₅ (IC₅₀s = 0.60, 0.12, 0.22, 0.83, and 0.41 nM, respectively, in CCL39 cells expressing human recombinant receptors).² It inhibits cAMP accumulation induced by forskolin in CCL39 cells expressing human recombinant SST₁, SST₂, SST₃, SST₄, and SST₅ (EC₅₀s = 5.13, 1.91, 6.46, 2.95, and 3.55 nM, respectively).³ Somatostatin-28 stimulates growth hormone (GH) release from primary porcine pituitary cells when used at a concentration of 1 fM.⁴ It inhibits acid secretion induced by gastrin I and IBMX in isolated rat gastric mucosa (EC₅₀s = 27 and 252 nM, respectively).⁵ In vivo, somatostatin-28 dose-dependently increases basal and pentagastrin-induced gastric acid secretion in rats.⁶

1.Lucey, M.R.Endogenous somatostatin and the gutGut27(4)457-467(1986) 2.Siehler, S., Seuwen, K., and Hoyer, D.Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studiesNaunyn Schmiedebergs Arch. Pharmacol.360(5)488-499(1999) 3.Siehler, S., and Hoyer, D.Characterisation of human recombinant somatostatin receptors. 3. Modulation of adenylate cyclase activityNaunyn Schmiedebergs Arch. Pharmacol.360(5)510-521(1999) 4.RamÍrez, J.L., Torronteras, R., CastaÑo, J.P., et al.Somatostatin plays a dual, stimulatory/inhibitory role in the control of growth hormone secretion by two somatotrope subpopulations from porcine pituitaryJ. Neuroendocrinol.9(11)841-848(1997) 5.Wyatt, M.A., Jarvie, E., Feniuk, W., et al.Somatostatin sst2 receptor-mediated inhibition of parietal cell function in rat isolated gastric mucosaBr. J. Pharmacol.119(5)905-910(1996) 6.Seefried, G., Schmidtler, J., and Schwille, P.O.Gastric secretion and gastrin under progressive doses of somatostatin-14 and -28 administered intraperitoneally to the ratPeptides9(2)249-255(1988)